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Bone Abstracts (2013) 1 ES2.3 | DOI: 10.1530/boneabs.1.ES2.3
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Medical University, Graz, Austria.


Low vitamin D serum levels have been associated with a considerable number of diseases and conditions and have attracted significant attention of the scientific community as well as of health authorities all over the world. However, discussions and controversies are ongoing about the reliability, significance and correct ranges of low vitamin D serum levels. A central goal is therefore the reliable measurement of circulating vitamin D, regarded as the best measure of an individual’s vitamin D status.

In addition to the main analyte 25(OH)vitamin D3, several other forms of vitamin D and its metabolites has to be taken into account, such as 1.25(OH)2 vitamin D. A C-3 epimer of vitamin D, metabolites like 24.25(OH)2 vitamin D and other members of this secosteroid family, as well as the dualism of D3 and D2 will be the topic of this lecture.

The technical analysis of vitamin D (and its subforms) started by using radioimmunological measurements. Commercially available enzyme-linked assays followed, either by manual or automated techniques. HPLC and/including tandem mass spectrometry of several types (MS–MS, LC–MS, GC–MS) provide a differentiated profile of vitamin D measurement.

A number of efforts to evaluate, validate and unify these techniques are on the way. The establishment of standardized measurements is of considerable value for the comparison of vitamin D analyses and their quality check in routine and research labs.

For scientific and practical purposes, the measurement of vitamin D not only requires reliable laboratory methods, but also international guidelines for the interpretation of the results. Furthermore, regular measurements, especially concerning high risk patients as well as a treating-strategy for low vitamin D levels need to be discussed. This lecture will provide insights into the complex analytics of vitamin D as well as the interpretation and consequences of low vitamin D levels.

Volume 1

European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

European Calcified Tissue Society 

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Low vitamin D (<1 min ago)

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