Bone Abstracts (2013) 1 PP355 | DOI: 10.1530/boneabs.1.PP355

Diabetes and obesity as independent risk factors for osteoporosis in postmenopausal women: a population study of 3354 people: first results of the PROF Project (Prevention of Osteoporosis and Fractures)

Cosimo Neglia1,3, Alberto Argentiero1,2, Giovanna Chitano1, Nadia Agnello1, Giuseppe Quarta1, Vincenzo Caiaffa4, Alessandro Distante1 & Prisco Piscitelli1

1ISBEM- Isituto Scientifico Biomedico Euro Mediterraneo, Brindisi, Apulia, Italy; 2University of Pisa, Pisa, Italy; 3University of Salento, Lecce, Italy; 4Department of Orthopedy, Local Health Authority of Taranto, Taranto, Italy.

Objectives: We aimed to analyze bone mineralization in postmenopausal women of Southern Apulia and to evaluate the effect of obesity-related phenotypes as BMI ≥30 kg/m2, diabetes, hypertension and cardiovascular diseases.

Methods: The PROF project is a population-based study on 3.356 subjects (40–99 years) analyzed by phalangeal quantitative ultrasound (QUS) to evaluate bone mineral status. A total of 2.756 postmenopausal women were involved and examined by phalangeal QUS based on the transmission of ultrasound through the proximal phalanges (digits II–V). We collected personal, anthropometric and clinical data for each subjects analyzed. The primary outcome of phalangeal QUS was AD- SoS (Amplitude dependent Speed of Sound) T score.

Logistic regression analysis was used to evaluated odds ratios (95% CI) of osteoporosis in subjects with obesity, diabetes, cardiovascular disease and hypertension. Results were adjusted by age, physical activity and use of drugs causing osteoporosis. According to the WHO criteria, osteoporosis status was defined as T- Score ≤3.2 S.D. the average value registered in young healthy women.

Results: Mean age of postmenopausal women was 64±9.5 years and mean BMI was 28.7±3.5.

Pearson correlation analysis revealed a negative association between T score and BMI (P<0.001). Significant odds ratio of osteoporosis status adjusted for age, physical activity and use of drugs causing osteoporosis were observed in women affected by diabetes and obesity, being OR (95% CI) respectively 1.39 (1.05–1.83) and 1.46 (1.20–1.78).

Conclusions: Diabetes and obesity in postmenopausal women with the characteristics of the examined population increase the risk of osteoporosis independently from the effect of the age, physical activity and drugs causing osteoporosis.