Objectives: We aimed to analyze bone mineralization in postmenopausal women of Southern Apulia and to evaluate the effect of obesity-related phenotypes as BMI ≥30 kg/m2, diabetes, hypertension and cardiovascular diseases.
Methods: The PROF project is a population-based study on 3.356 subjects (4099 years) analyzed by phalangeal quantitative ultrasound (QUS) to evaluate bone mineral status. A total of 2.756 postmenopausal women were involved and examined by phalangeal QUS based on the transmission of ultrasound through the proximal phalanges (digits IIV). We collected personal, anthropometric and clinical data for each subjects analyzed. The primary outcome of phalangeal QUS was AD- SoS (Amplitude dependent Speed of Sound) T score.
Logistic regression analysis was used to evaluated odds ratios (95% CI) of osteoporosis in subjects with obesity, diabetes, cardiovascular disease and hypertension. Results were adjusted by age, physical activity and use of drugs causing osteoporosis. According to the WHO criteria, osteoporosis status was defined as T- Score ≤3.2 S.D. the average value registered in young healthy women.
Results: Mean age of postmenopausal women was 64±9.5 years and mean BMI was 28.7±3.5.
Pearson correlation analysis revealed a negative association between T score and BMI (P<0.001). Significant odds ratio of osteoporosis status adjusted for age, physical activity and use of drugs causing osteoporosis were observed in women affected by diabetes and obesity, being OR (95% CI) respectively 1.39 (1.051.83) and 1.46 (1.201.78).
Conclusions: Diabetes and obesity in postmenopausal women with the characteristics of the examined population increase the risk of osteoporosis independently from the effect of the age, physical activity and drugs causing osteoporosis.
18 - 21 May 2013
European Calcified Tissue Society