Bone Abstracts

Introduction: Aggressive periodontitis (AgP) is an inflammatory disease causing rapid loss of teeth in young patients.

Aim: Determine degree of impact of COL1A1 gene on likelihood of AgP development.

Materials and methods: Study included 47 patients with AgP, 40 patients with osteoporosis (OP), and 64 healthy patients (HP). Polymorphic variant c.104-441G>T (COL1A1) was studied. Statistics: Fisher’s, P≤0.05/OR/95% CI.

Results: Genotype distribution in AgP patients and HP showed that likelihood of AgP development increased sevenfold if patient was carrier of T/T genotype (P=0.002/OR=7.0/95% CI 2.26–21.47). Genotype distribution in OP and HP groups showed that the risk of OP development is significantly related to G/G genotype which increases the likelihood of OP development 4.3-fold (P=0.001/OR=4.3/95% CI 1.84–10.11). Moreover, study of OR showed that genotype G/G is protective for AgP patients as its carriers are significantly less likely to develop OP (P=0.05/OR=0.5/95% CI 0.21–0.99).

Discussion: c.104-441G>T can increase the risk of OP development in G/G genotype subjects and AgP in T/T genotype subjects. So it can be a marker of both diseases. T/T variant in proband genotype can be a predictor of AgP development in close relatives. Thus analysis of this gene is recommended to detect disease at an early stage, and differential diagnosis of AgP from other forms of periodontitis.