ECTS2013 Poster Presentations Osteoporosis: evaluation and imaging (31 abstracts)
Low testosterone levels are associated with poor peripheral bone mineral density and quantitative bone ultrasound at phalanges and calcaneus in healthy elderly men
Jesus Maria Lavado-Garcia , Purificación Rey-Sanchez , Carmen Costa-Fernandez , Mariana Martínez , Alejo Leal , Francisco Jose Rodriguez-Velasco & Juan Diego Pedrera-Zamorano
Metabolic Bone Diseases Research Group, Cáceres, Spain.
Context: Variations in sex hormones influence bone health in men. Aging in men is associated with a decrease in testosterone (T) levels.
Aims: To examine the relationship between T levels and changes in bone health status as measured by quantitative ultrasound (QUS) at the phalanges and the os calcis and by peripheral bone mineral density (pBMD) at the phalanges in healthy elderly Spanish men.
Methods and material: We examined 162 men 65–88 years of age, and total serum T concentrations were assessed. Serum total T <300 ng/dl was used as the threshold for biochemical T deficiency. QUS at the phalanges and the os calcis and by pBMD at the phalanges was measured.
Results: The sample was divided into low or normal T levels, and both groups were matched for age, weight, height and BMI (P>0.05 for all the comparisons). All measured bone parameters were higher in the normal serum T group (P<0.05). Multiple regression analysis revealed that serum T was an independent predictor of both QUS at the calcaneus and pBMD. Serum T exhibited a sensitivity and specificity of 42.1 and 90.2%, respectively, for the detection of lower or higher risks of osteoporosis (based on a T-score<−2 by phalangeal DXA).
Conclusions: Our data indicated that T was an independent determinant of QUS at the os calcis and pBMD at the phalanges in elderly Spanish men.
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