Objective: The aim of this study was to assess the association between bone mineral density (BMD) and coronary atherosclerosis in healthy postmenopausal women.
Methods: We performed a retrospective review of 252 postmenopausal women who visited the health promotion center for a routine checkup, after excluding participants who had factors affecting BMD and coronary artery disease. BMD of the lumbar spine and proximal femur was evaluated by dual-energy X-ray absorptiometry. Coronary atherosclerosis was assessed by 64-row multidetector computed tomography. Participants were divided into normal bone and osteopeniaosteoporosis groups according to the T scores of their lumbar spine or femur neck.
Results: Participants with osteopenia-osteoporosis had a significantly higher proportion of coronary atherosclerosis than those with normal BMD at the lumbar spine (P=0.003) and femur neck (P=0.004). Osteopenia-osteoporosis at the lumbar spine (OR, 2.86; 95% CI, 1.127.27) and femur neck (OR, 3.35; 95% CI, 1.0710.57) was associated with coronary atherosclerosis after controlling age and cardiovascular risk factors.
Conclusion: Decreased BMD is associated with coronary atherosclerosis in healthy postmenopausal women, independent of age and cardiovascular risk factors. Postmenopausal women with decreased bone mineral density may have higher risk of coronary atherosclerosis.
18 - 21 May 2013
European Calcified Tissue Society