Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2013) 1 PP399 | DOI: 10.1530/boneabs.1.PP399

ECTS2013 Poster Presentations Osteoporosis: treatment (64 abstracts)

Assessment of serum 25-hydroxyvitamin D concentrations in postmenopausal osteoporotic women: a retrospective study to evaluate long-term treatment with vitamin D3

Camilla Sand Andersen 1, , Peter Vestergaard 1 , Parisa Gazerani 1 & Hans Christian Hoeck 2


1Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; 2Center for Clinical and Basic Research (CCBR), Aalborg, Denmark.


Introduction: The purpose of this study was to evaluate whether daily treatment with 400 IU vitamin D3 was sufficient to maintain 25-hydroxyvitamin D (25(OH)D) concentrations above 60 nmol/l over a 3-year period. In addition, the study aimed to clarify if any differences existed in serum 25(OH)D between pre-supplemented women and women who already had serum 25(OH)D above 60 nmol/l at screening.

Methods: Serum samples drawn from 251 postmenopausal osteoporotic women over a 3-year period were analyzed for 25(OH)D, parathyroid hormone (PTH), and phosphate. Furthermore, a comprehensive patient file review was performed to collect patient characteristics and laboratory results. RM-ANOVA was applied to evaluate treatment effect over time. Approval was obtained from The Danish Scientific Ethical Committee, Region North Jutland, Denmark (N-20120060).

Results: Serum 25(OH)D increased significantly over the 3-year period (P>0.001). The mean increase was 24 nmol/l. Pre-supplemented women had a significantly lower mean 25(OH)D concentration compared to non-pre-supplemented women (P<0.001) but remained above 60 nmol/l. Season significantly interacted with 25(OH)D concentrations (P<0.001) and concentrations measured during winter were significantly elevated compared to other seasons (P<0.05).

Conclusions: It appears that daily treatment with 400 IU vitamin D3 over a 3-year period is sufficient to maintain serum 25(OH)D above 60 nmol/l.

Volume 1

European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

European Calcified Tissue Society 

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