Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

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European Calcified Tissue Society Congress 2013, 18 - 22 May 2013; Lisbon, Portugal

Oral Communications

Bone quality and fracture repair - animal models

ba0001oc2.1 | Bone quality and fracture repair - animal models | ECTS2013

Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of duchenne muscular dystrophy

Puolakkainen Tero , Ma Hongqiang , Pasternack Arja , Kainulainen Heikki , Ritvos Olli , Heikinheimo Kristiina , Hulmi Juha , Kiviranta Riku

Patients with Duchenne muscular dystrophy (DMD) carry a mutation in the dystrophin gene that leads to progressive muscle degeneration. In addition, DMD patients develop low bone mass especially in long bones and have high incidence of fractures. The underlying mechanisms for decreased bone mass remain unclear but muscle weakness and increased IL6 levels may play a role. Inhibition of activin/myostatin pathway has emerged as a novel approach to increase muscle mass and strength...

ba0001oc2.2 | Bone quality and fracture repair - animal models | ECTS2013

Intermittent human parathyroid hormone (1–84) treatment improves bone mass and bone defect healing in rats with type 2 diabetes mellitus

Hamann Christine , Picke Ann-Kristin , Rauner Martina , Bernhardt Ricardo , Campbell Graeme , Gluer Claus-Christian , Hofbauer Lorenz C

The pathogenesis of skeletal fragility in diabetes mellitus is poorly defined and efficient therapies are limited. Zucker diabetic fatty (ZDF) rats with type 2 diabetes mellitus display low bone mass and delayed bone defect healing. We tested whether intermittent treatment with human parathyroid hormone 1–84 (PTH) increases bone mass and bone defect regeneration in diabetic rats.A subcritical gap defect was created at the femur of 10 weeks old diabe...

ba0001oc2.3 | Bone quality and fracture repair - animal models | ECTS2013

Low-magnitude high-frequency vibration improves fracture healing in aged, ovariectomized mice

Wehrle Esther , Bindl Ronny , Wehner Tim , Heilmann Aline , Fischer Lena , Noland Jarrod , Amling Michael , Ignatius Anita

Introduction: Fracture healing is impaired in aged and osteoporotic patients. Because bone formation is tightly regulated by the mechanical conditions in the fracture gap and because suitable mechanical stimuli improve fracture healing (Claes et al. 1998), we investigated whether low-magnitude high-frequency vibration (LMHFV; Rubin et al. 2004) is able to improve delayed fracture healing induced by age and ovariectomy in mice.Sudy desig...

ba0001oc2.4 | Bone quality and fracture repair - animal models | ECTS2013

PPARβ deficiency induces muscle and bone loss with aging but does not impair the bone biomechanical response to loading: a sarco-osteopenic mouse model

Bonnet Nicolas , Desvergne Beatrice , Ferrari Serge

Pparβ is crucial for muscle fatty acid oxidation. Pparβ−/− mice have reduced muscle strength, exercise performance, and also a decreased skeletal response to exercise. Here we investigate the influence of Pparβ on muscle and bone loss with aging, and its role on the bone biomechanical response to loading. Pparβ−/− and Pparβ+/+ mice were monitored at 1, 3 and 18...

ba0001oc2.5 | Bone quality and fracture repair - animal models | ECTS2013

Glucagon-like peptide 1 receptor is required for optimal bone strength and quality

Mieczkowska Aleksandra , Irwin Nigel , Flatt Peter R , Chappard Daniel , Mabilleau Guillaume

Objectives: Glucagon-like peptide 1 is secreted by intestinal L-cells into the blood supply in response to nutrients in the intestine. Although osteoblasts express the GLP-1 receptor (GLP-1R), the main action of the GLP-1/GLP-1R pathway in bone physiology and bone quality is unknown. The aim of the present study was to investigate bone strength and quality in a mouse model of GLP-1R deficiency.Materials/methods: Eight 16 weeks-old GLP-1R knock-out male m...

ba0001oc2.6 | Bone quality and fracture repair - animal models | ECTS2013

GH excess in bGH transgenic mice adversely affects bone density, architecture and quality

Lim Su-Vern , Marenzana Massimo , List Edward , Kopchick John , Korbonits Marta , Chenu Chantal

GH is an important anabolic hormone involved in the regulation of longitudinal bone growth. However, acromegaly patients have a higher prevalence of vertebral fractures despite normal bone mineral density (BMD), suggesting that GH overexpression has adverse effects on skeletal architecture and strength. We used giant bovine GH (bGH) transgenic mice to analyse the effects of high serum GH levels on BMD, architecture and mechanical strength. Five month-old hemizygous male bGH mi...