Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2013

Lisbon, Portugal
18 May 2013 - 22 May 2013

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European Calcified Tissue Society Congress 2013, 18 - 22 May 2013; Lisbon, Portugal

Poster Presentations

Steroid hormones and receptors

ba0001pp509 | Steroid hormones and receptors | ECTS2013

Prostate tumorigenesis in estrogen receptor β inactivated, prostate targeted fibroblast growth factor 8B transgenic mice

Elo Teresa , Yu Lan , Valve Eeva , Makela Sari , Harkonen Pirkko

Prostate cancer is a commonly diagnosed malignancy in Europe. Bone is one of the common metastasis sites. There is increasing evidence for estrogen involvement in the prostate tumorigenesis. ERβ knockout (BERKO) mice have been reported to have anti-proliferative, anti-inflammatory and potential anti-tumorigenic functions of ERβ. However, prostate phenotype of BERKO mice has been under debate.The potential effect of ERβ on prostate tumorgen...

ba0001pp510 | Steroid hormones and receptors | ECTS2013

Glucocorticoids inhibit bone formation independent of miRNA regulation

Liu Peng , Baschant Ulrike , Groth Marco , Baumgart Mario , Platzer Matthias , Jack Hans-Martin , Tuckermann Jan

: Glucocorticoid-induced osteoporosis (GIO) is the most frequent secondary osteoporosis in patients undergoing steroid therapy.Recently we demonstrated that the inhibition of bone formation in GIO is occurring in part via the suppression of autocrine cytokines by the glucocorticoid receptor (GR) monomer in osteoblasts (Cell Metab 11, 517–531). Since emerging evidences indicate that microRNAs (miRNAs) play a critical role in the differentiat...

ba0001pp511 | Steroid hormones and receptors | ECTS2013

The survey perception by 85 specialist physicians of the corticosteroid adverse events

Nassar Kawtar , Janani Saadia , Rachidi Wafaa , Mkinsi Ouafaa

Introduction:: The pharmacological glucocorticoids used have an anti-inflammatory and immunosuppressive action, but therapeutic gain is often accompanied by side effects. Widely prescribed, both by medical specialists and generalists, our work objective is to evaluate the perception by specialist medicine physicians of the impact of the discomfort caused by corticosteroid-induced adverse events.Methods:: We conducted a descriptive survey with 85 speciali...

ba0001pp512 | Steroid hormones and receptors | ECTS2013

Positive regulation of osteogenesis by bile acid through FXR

Shin Chan Soo , Cho Sun Wook , Park Hyojung , Yang Jae-Yeon , Kim Sang Wan , Park Young Joo , Yim Mijung , Kim Jung Eun , Kim Seong Yeon , An Jee Hyun

Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily, which functions as bile acid sensor controlling the bile acid homeostasis. We have investigated the role of FXR in regulating bone metabolism in vivo. We have identified expression of FXR in calvaria and bone marrow cells, which was gradually increased during osteoblastic differentiation in vitro. Deletion of FXR in vivo has resulted in significant reduction in bone mineral density by...

ba0001pp513 | Steroid hormones and receptors | ECTS2013

Indole-3-carbinol and epigallocatechin-3-gallate for complex treatment of inflammatory periodontal diseases in female patients with gynecological pathologies

Atrushkevich Victoria , Zabalueva Ella , Zoryan Elena

Introduction: Previous studies demonstrated that estrogen deficit in female patients causes inflammatory periodontal diseases. Sex steroids act by interacting with intracellular receptors located in odontoblasts, osteoblasts, gingival fibroblasts, and periodontal ligament cells. Inflammation in periodontal tissue is caused by excessive concentration of sex hormone receptors in oral mucosa.Aim: Studying the influence of indole-3-carbinol (I3C) and epigall...