ICCBH2013 Poster Presentations (1) (201 abstracts)
Celiac disease and bone disorders: diagnosis age influence
Oscar Brunetto 1 , Ana Arias Cau 1 , Claudia Insua 1 & Chriatian Boggio Marzet 2
1Hospital Gral de Niños Pedro de Elizalde, Buenos Aires, Argentina; 2Hospital Gral de Agudos I Pirovano, Buenos Aires, Argentina.
Celiac disease (CD) is a frequent cause of malabsortion in childhood and affects calcium and vitamin D absorption.
Aim: Analyze the vitamin D levels and bone mineral density (BMD) at diagnosis in patients affected with CD, and the influence of the age of diagnosis in the clinical presentation.
Patient: 52 patients (female: 26) were evaluated.
Results: The percentage with vitamin D deficiency (<20 ng/ml) was 37, 7% (n=20) at the moment of diagnosis and 26.4% (n: 14) of the patients had BMD LS below 2 S.D.(Table 1). In the whole group we found positive correlation between: BMD Z-score and vitamin D levels (P<0.01, r: 0.527) and BMD Z-score and chronological age at the moment of diagnosis (P<0.05 r: −0, 345). Levels of 25(OH)D correlated with and BMD Z-score (P<0.005, r: 0.486) in the group with more than 6 years old at diagnosis.
| Whole group (n: 52) | ≤6 years old at diagnosis (n: 16) | > 6 años years old at diagnosis (n: 36) | |
| Age at diagnosis (year) | 9.11 (±4.60) (1.6 – 18) | 3.44 (±1.28) | 11.6 (±2.99) |
| Z-score height (S.D.) | −0.82 (±1.46) | −0.40(±0.79) | −1.01 (±1.66) |
| Z-score weight (DS) | −0.73 (±1.36) | −0.33 (±1.03) | −0.90 (±1.47) |
| BMI | 18.11 (±4.14) | 18.10 (±0.9) | 17.30 (±3.74) |
| BMD Lumbar Spine (S.D.) | −1.1 (±1.5) | −0.57(±1.3)* | −1.33 (±1.15)* |
| BMD Lumbar Spine (g/cm2) | 0.642 (±0.18) | 0.48 (±0.45) | 0.687 (±0.035) |
| 25 (OH) D (ng/ml) | 25.58 (±13.48) | 30.26 (±10.36)† | 22.94 (±11.94)† |
| †P<0.03. *P<0.02 LS: L2 – L4 Lumbar Spine | |||
Conclusions: We found an important percentage of vitamin D deficiency and low bone mass at the moment of diagnosis in the whole group. The age at the diagnosis influenced bone mineral density and biochemical manifestations. Our results suggest that the early diagnosis and treatment is essential for the bone health of patients affected with CD.
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