Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2013) 2 P46 | DOI: 10.1530/boneabs.2.P46

ICCBH2013 Poster Presentations (1) (201 abstracts)

Interactions of adipokines and bone metabolism in patients with severe juvenile idiopathic arthritis

Kati Markula-Patjas 1 , Kaisa Ivaska 2 , Minna Pekkinen 3 , Sture Andersson 4 , Heli Viljakainen 4 & Outi Mäkitie 3,


1Paediatric Research Centre, University of Tampere and Tampere University Hospital, Tampere, Finland; 2Department of Cell Biology and Anatomy, Institute of Biomedicine, University of Turku, Turku, Finland; 3Folkhälsan Research Center, Helsinki, Finland; 4Children’s Hospital, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland.


Objectives: The skeleton and adipose tissue interact. Our aim was to evaluate the interactions between adipokines and bone metabolism, and their association with disease-related factors in patients with severe juvenile idiopathic arthritis (JIA).

Methods: The study included 49 patients (median age 14.8 years, median disease duration 10.2 years) with refractory polyarticular JIA and 89 sex- and age-matched healthy controls. The subjects underwent clinical examination, body composition measurement with DXA and analyses for leptin, adiponectin and bone turnover markers.

Results: Patients with JIA were shorter and more often overweight (P=0.001) or obese (P<0.001) than controls. They had significantly higher leptin levels, even when adjusted for fat mass (P<0.001), and similar adiponectin but slightly lower adiponectin-to-fat mass ratio (P=0.073) than controls. Concentrations of bone formation markers were similar, but the level of carboxyterminal telopeptide of type I collagen (ICTP) (P=0.006) and the ratios of ICTP to osteocalcin or alkaline phosphatase were higher in the patients, indicating increased bone resorption. In controls, the inverse association between leptin and bone turnover markers was largely dependent of fat mass. Conversely, in patients the inverse association between leptin and bone formation markers was strengthened and became significant when adjusted for fat mass. Leptin, adiponectin or bone markers did not associate with disease duration or activity. Adiponectin associated inversely with ICTP in the controls.

Conclusions: We observed high adiposity and thus increased risk for metabolic complications in a cohort of patients with severe JIA. This was accompanied with increased bone resorption. Serum leptin was higher in patients, even when adjusted for fat mass. In patients leptin tended to associate inversely with bone formation markers but it did not associate with disease activity.

Volume 2

6th International Conference on Children's Bone Health

Rotterdam, The Netherlands
22 Jun 2013 - 25 Jun 2013

ICCBH 

Browse other volumes

Article tools

My recent searches

No recent searches.