Bone Abstracts

Perinatal infections appreciably defines the level’s of the neonatal deseases and death rates. The systemic inflammatory response syndrome at the infections can promote the softening of the bone’s tissue in pregnant women and their fetuses.

Objectives: Definition of the connection of the level’s calcium-regulated hormones and bone tissue remodeling marker’s in blood at 32 (II) healthy and 48 (I) pregnant women with perinatal infections, also in the funic blood at their fetuses with development of bone-muscular system of children.

Method: In dynamics were defined the blood levels of 25 (OH) vitamin D, parathyroid hormone (PTG), osteocalcin (OC), β-CrossLaps by immunoassay methods. At children’ birth anthropometrical data, development of the bone-muscular system, quality of neonatal period’s reflexes were estimated.

Results: At the third newborns from I-st group clinical attributes of insufficient mineralization of bone system are revealed. At women I-st group concentration of vitamin D (72.17±3.29 vs 84.22±5.08 mmol/l) was authentically smaller; in the funic blood was above (85.39±6.72 vs 51.40±3.01 mmol/l, P<0.01). Significant distinction in PTG levels between groups at women (25.46±2.20 vs 30.24±1.61 pg/ml) and in funic blood (6.12±0.14 vs 6.14±0.12 pg/ml, P>0.05) is not revealed. Concentration of OC (90.37±5.96 vs 53.00±6.09 ng/ml, P<0.01) and β-Cross-Laps in the umbilical cord (0.85±0.03 vs 0.65±0.04 pg/ml, P<0.01) was above in II-nd group. At women with infection bones synthesis and resorbtion’s speed were significant above (OK-24.46±1.79 vs 18.48±1.17 ng/ml, β-CrossLaps – 0.80±0.07 vs 0.61±0.04 pg/ml).

Conclusion: At women with perinatal infections and their newborns infringement of processes of regulation of the bone’s tissue metabolism and the mineralization is observed.