Searchable abstracts of presentations at key conferences on calcified tissues
Bone Abstracts (2014) 3 PP101 | DOI: 10.1530/boneabs.3.PP101

ECTS2014 Poster Presentations Cancer and bone: basic, translational and clinical (11 abstracts)

The effect of granulocyte colony-stimulating factor in adults undergoing autologous peripheral blood stem cell collection

Karin Amrein 1 , Camilla Drexler 2 , Susanna Oczko 2 , Nazanin Sareban 2 , Sabine Sipurzynski 2 , Thomas R. Pieber 1 , Gerhard Lanzer 2 , Doris Wagner 3 & Astrid Fahrleitner-Pammer 1


1Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University, Graz, Austria; 2Medical University, University Clinic of Blood Group Serology and Transfusion Medicine, Graz, Austria; 3Department of Surgery, Medical University, Graz, Austria.


Introduction: Granulocyte colony-stimulating factor (G-CSF) is widely used to mobilize peripheral blood stem cells (PBSC) and enable PBSC collection by apheresis. Although bone pain is a common adverse event following G-CSF treatment, little is known on its effect on bone metabolism.

Methods: Markers of bone turnover (OC, osteocalcin, β-CTx, bALP, C-terminal telopeptide of type I collagen, bone specific alkaline phosphatase, TRAP, tartrate resistant acid phosphatase) and mineral metabolism were assessed in adult patients with haematological malignancy who received G-CSF for autologous PBSC collection. Analyses were repeated after G-CSF stimulation. Patients with glomerular filtration rate <30 ml/min were excluded from analysis.

Results: Eighteen subjects were included (ten men, eight women, mean age 48±11 years, BMI 24.5±2.9 kg/m2). ß-CTX and bALP were elevated already at baseline. OC, bALP and TRAP were significantly altered by G-CSF, while ß-CTX and calcium levels remained unchanged (Table 1).

Table 1 Markers of bone turnover in adult patients before and after G-CSF
Biochemical marker, reference rangeBefore G-CSFAfter G-CSFP
β-CTx, 0.06–0.35 ng/ml0.40±0.340.42±0.320.57
Osteocalcin, 1.0–35.0 ng/ml25.3±18.716.5±10.00.007
bALP, 7.5–20.6 U/l22.8±17.733.7±17.90.002
TRAP, 2.59–4.03 μg/l3.41±1.572.78±1.150.002
Total calcium, 2.25–2.65 mmol/l2.30±0.142.31±0.190.88

Conclusion: Our results demonstrate that high-dose G-CSF acutely affects bone metabolism. The clinical relevance of these finding remains unclear, but further research is warranted to confirm our findings and ascertain long-term skeletal health in this vulnerable population.

Volume 3

European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

European Calcified Tissue Society 

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