Background and objectives: The association between excess calcium intake and cardiovascular mortality has been reported, but the association has not yet been explored according to serum vitamin D status. Thus, we investigated the relation of dietary calcium intake and Framingham risk score (FRS) according to serum 25-hydroxyvitamin D (25(OH)D) status.
Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years from the data of the Korea National Health and Nutrition Examination Survey (KNHANES, 2008-200-11) were selected for this cross-sectional study. Daily dietary calcium intake was categorized into <300, 300600, 600900, 9001,200, and >1200 mg/day and serum 25(OH)D concentration classified into <50, 5075, and>75 mmol/l. The FRS was compared by the daily dietary calcium intake categories according to 25(OH)D concentration after adjustment with relevant variables in both genders.
Result: Higher FRS was observed in both <300 and >1200 mg of dietary calcium intake groups of males and <300 mg of females without adjustment. The significantly higher FRS were remained in the <300 and >1200 mg of dietary calcium intake in both genders after relevant variables adjustments. FRS was significantly higher in the group of >1,200 mg of dietary calcium intake group and serum 25(OH)D <50 nmol/l, which is vitamin D deficient group, only in male, not in female.
Conclusion: Very low (<300 mg/day) and excess (>1200 mg/day) dietary calcium intake was related with higher FRS in both genders, in particular, higher FRS was observed in the excess (>1200 mg/day) dietary calcium intake under vitamin D deficient (<50 nmol/l) males.
17 - 20 May 2014
European Calcified Tissue Society