Bone Abstracts (2014) 3 PP391 | DOI: 10.1530/boneabs.3.PP391

Excess dietary calcium intake associated with higher Framingham risk score in 25-hydroxyvitamin D deficient male; analysis of the Korea National Health and Nutrition Examination Survey (KNHANES 2008-2011)

Sung-Jin Choi1, Nam-Seok Joo1, Se-Il Kim1, Go-Eun Song2 & Jin-Ho Kim1


1Ajou University School of Medicine, Suwon, Gyeonggi-do, Republic of Korea; 2CHA Anti-Aging Institute, Seoul, Republic of Korea.


Background and objectives: The association between excess calcium intake and cardiovascular mortality has been reported, but the association has not yet been explored according to serum vitamin D status. Thus, we investigated the relation of dietary calcium intake and Framingham risk score (FRS) according to serum 25-hydroxyvitamin D (25(OH)D) status.

Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years from the data of the Korea National Health and Nutrition Examination Survey (KNHANES, 2008-200-11) were selected for this cross-sectional study. Daily dietary calcium intake was categorized into <300, 300–600, 600–900, 900–1,200, and >1200 mg/day and serum 25(OH)D concentration classified into <50, 50–75, and>75 mmol/l. The FRS was compared by the daily dietary calcium intake categories according to 25(OH)D concentration after adjustment with relevant variables in both genders.

Result: Higher FRS was observed in both <300 and >1200 mg of dietary calcium intake groups of males and <300 mg of females without adjustment. The significantly higher FRS were remained in the <300 and >1200 mg of dietary calcium intake in both genders after relevant variables adjustments. FRS was significantly higher in the group of >1,200 mg of dietary calcium intake group and serum 25(OH)D <50 nmol/l, which is vitamin D deficient group, only in male, not in female.

Conclusion: Very low (<300 mg/day) and excess (>1200 mg/day) dietary calcium intake was related with higher FRS in both genders, in particular, higher FRS was observed in the excess (>1200 mg/day) dietary calcium intake under vitamin D deficient (<50 nmol/l) males.

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