Background and objective: Recent studies have demonstrated that higher serum 25-hydroxyvitamin D (25(OH)D) had a favorable effect on bone health. Osteocalcin, however, according to its serum concentration showed different outcomes for bone and aortic calcification. The aim of this cross-sectional study was to compare the bone mineral density (BMD) and coronary artery calcification score (CACS) according to the serum concentration of 25-hydroxyvitamin D and osteocalcin.
Methods: A total of 241 subjects data of the Health Promotion Center of CHA Anti-aging Institute, CHA University, Seoul, Republic of Korea, were selected. All data had serum 25(OH)D, osteocalcin, BMD, and CACS. We divided serum 25(OH)D and osteocalcin into two groups by their median concentration. BMD and LogCACS were compared according to four different groups of 25(OH)D and osteocalcin; low 25(OH)D with low osteocalcin, high 25(OH)D with low osteocalcin, low 25(OH)D with high osteocalcin, and high 25(OH)D with high osteocalcin.
Results: Serum glucose and triglyceride concentration was significantly low in the high 25(OH)D with high osteocalcin group. On the contrary, femur neck BMD (FNBMD) and total hip BMD (THBMD) were the highest in the high 25(OH)D with low osteocalcin group. As the same manner, LogCACS was the lowest, but not significant (P=0.072), in the high 25(OH)D with high osteocalcin group and the FNBMD (P=0.025) and THBMD (P=0.008) were the highest in the high 25(OH)D with low osteocalcin group by ANCOVA test after adjustment with relevant variables.
Conclusion: Higher serum 25(OH)D with low osteocalcin showed significant association with higher FMBMD and THBMD. In addition, the high 25(OH)D with high osteocalcin group had a trend to have low LogCACS, which may mean high serum 25(OH)D may have favorable effect on LogCACS against high osteocalcin.
17 - 20 May 2014
European Calcified Tissue Society