Bone Abstracts

Hormone replacement therapy (HRT) comprises estrogen, with or without progestogen addition, given to postmenopausal women. HRT is by far the most effective treatment for the relief of menopausal symptoms such as vasomotor and genito-urinary symptoms. It is as effective as alternative treatments for the prevention of postmenopausal osteoporosis. It increases bone mass, reduces bone turnover, and reduces fracture risk at all the important skeletal sites. It has a beneficial effe...

Currently menopausal hormone treatment (HT) is not recommended for the prevention of chronic disease. This recommendation is based on reputable science relying largely on the Women’s Health Initiative (WHI), a large methodologically sound, long-term, randomized clinical trial (RCT) of 27 347 women age 50–79 years. A RCT is considered level two evidence in the hierarchy of evidence only below a systematic review of several RCTs. The WHI HT trials were designed to dete...