Bone Abstracts

Several independent international studies have shown increased bone fracture rates in patients with hyponatremia (HN). A likely major contributor to this finding is gait instability and increased falls in HN patients. Studies in experimental animals have also demonstrated HN-induced bone loss, and analysis of human subjects in NHANES III showed a significantly increased odds ratio for osteoporosis by hip DXA in the HN subjects in this database. In vitro studies of the...

Therapeutic glucocorticoids are still widely used for their anti-inflammatory effects. There are however significant side effects associated with their use. These include effects on bone leading to osteoporosis and fracture but also on muscle (increasing risk of falls) and systemic fuel metabolism (leading to diabetes and increased cardiovascular risk). Research over many decades has tried to develop agents which retain the anti-inflammatory effects of glucocorticoids but have...

Hypothyroidism delays bone development and linear growth, whereas thyrotoxicosis accelerates skeletal development and is an important risk factor for osteoporosis in adulthood. Even sub-clinical thyrotoxicosis is associated with fracture, and treatment with thyroxine at doses that suppress TSH results in increased bone turnover and low BMD in postmenopausal women.To investigate the mechanism of T3 action in the skeleton, we characterized mice ...