Bone Abstracts

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During the last 12 months we have worked on 2 projects that I will talk about at the ECTS 2014 conference. The first is our work on collagen fibril formation at the cell surface, using tendon as a model tissue. We have shown that the transport of newly-formed fibrils at the plasma membrane requires non-muscle myosin II. The second is that tendon is a peripheral clock tissue. We have shown that the tendons in mice lacking circadian rhythm have abnormal collagen fibril assembly ...

Skeletal diseases are a large and diverse group of rare monogenic phenotypes and there are more than 450 unique and well-characterised chondrodysplasia phenotypes that range in severity from relatively mild to severe and lethal forms. Studying these genetically tractable chondrodysplasia phenotypes provides insight into disease pathways that may be relevant to the more common and polygenic forms of OA.Pseudoachondroplasia (PSACH) and multiple epiphyseal ...