Searchable abstracts of presentations at key conferences on calcified tissues
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European Calcified Tissue Society Congress 2014

Prague, Czech Republic
17 May 2014 - 20 May 2014

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European Calcified Tissue Society Annual Congress, 17 - 20 May 2014; Prague, Czech Republic

Poster Presentations

Osteoporosis: evaluation and imaging

ba0003pp213 | Osteoporosis: evaluation and imaging | ECTS2014

HIV patients have deteriorated bone material properties assessed by in vivo microindentation

Guerri-Fernandez Robert , Villar-Garcia Judit , Molina-Morant Daniel , Torres-del-Pliego Elisa , Garcia-Giralt Natalia , Vilaplana-Marz Laia , Rodriguez Maria , Mena Alicia Gonzalez , Knobel Hernando , Nogues Xavier , Mellibovsky Lenoardo , Horcajada Juan Pablo , Diez-Perez Adolfo

There is a growing evidence of the association between HIV infection and fracture risk. Independently of its cause (antiretroviral therapy (ART) or HIV), what remains most important is a prompt diagnosis. Although densitometry is the gold standard, sometimes this technique is not as accurate as necessary in clinical practice. A new validated tool for early and more accurate diagnosis is presented.MethodsIn a HIV group of patients, ...

ba0003pp214 | Osteoporosis: evaluation and imaging | ECTS2014

Bone marrow densitometry by clinical high resolution computed tomography of human vertebrae

Pena Jaime , Campbell Graeme , Damm Timo , Barkmann Reinhard , Waldhausen Sonja , Thomsen Felix , Krause Matthias , Puschel Klaus , Gluer Claus C

Bone mineral density (BMD) as measured by quantitative computed tomography (QCT) is biased by the variable marrow composition since marrow fat reduces the apparent BMD. We developed a marrow densitometry (MD) method that identifies subvolumes in the vertebrae that consist of bone marrow only (bone voids) and determines their average mineral equivalent density values. The method was developed for use with in vivo high resolution QCT (HR-QCT). HR-QCT still has limited s...

ba0003pp215 | Osteoporosis: evaluation and imaging | ECTS2014

Bone quality in diabetes mellitus type 2

Jackuliak Peter , Killinger Zdenko , Payer Juraj

Diabetes is associated with increased risk of fracture, although type 2 diabetes mellitus (T2DM) is characterized by normal bone mineral density (BMD). Thus, diabetes may be associated with a reduction of bone strength that is not reflected in the measurement of BMD. It is very problematic to measure the bone quality in daily practice. Trabecular bone score (TBS) iNsight® is one of these tools, now available for routine clinical practice, that allows for refinement of mic...

ba0003pp216 | Osteoporosis: evaluation and imaging | ECTS2014

Correlation between osteoporosis and dental caries in Korean population

Park Ye Soo , mo Hong Sang , Choi Woong Hwan , Kang Byung Moon , Won Ye Yeon

Aging is associated with a loss of systemic bone mass and an increased risk of especially the spine and hip. Therefore bone loss of teeth and ridge resorption can occur in the mouth. However, results of several studies investing association between systemic bone density and oral health have varied. In this study, we investigated the relationship between osteoporosis and dental caries with the Korea National Health and Nutrition Examination Survey (KNHANES) conducted in 2008&#1...

ba0003pp217 | Osteoporosis: evaluation and imaging | ECTS2014

An observational study investigating the prevalence of anaemia in hip fracture patients

Frankland Stuart , Gupta Abhaya

Introduction: The blood loss sustained during hip fracture repair can be significant and is associated with a high-risk of post-operative anaemia. Anaemia may exacerbate chronic cardiac and pulmonary conditions suffered by this aging population leading to increased morbidity and mortality.Objective: To assess the prevalence and severity of anaemia throughout hospital admission in patients admitted with a fractured neck of femur.Met...

ba0003pp218 | Osteoporosis: evaluation and imaging | ECTS2014

Sacral insufficiency fracture associated with osteoporotic spinal compression fracture: analysis of incidence and clinical factors

Park Ye Soo , Seo Wan Sik , Heo Dong-Ryeol , Kang Byung Moon , Won Ye Yeon

Sacral insufficiency fracture is known as a common cause of lumbosacral pain developed without evident trauma in patients with osteoporotic spinal compression fracture. The purpose of study was to investigate the incidence and predisposing factors of sacral insufficiency fracture accompanied by osteoporotic spinal compression fracture.We carried out a retrospective study of 949 patients who were measured bone mineral densitometry (BMD) and showed osteopo...

ba0003pp219 | Osteoporosis: evaluation and imaging | ECTS2014

Experimental glucocorticoid-induced bone loss in mice is strongly influenced by the strain

Ersek Adel , Vattakuzhi Youridies , Clark Andrew R , Horwood Nicole J

Glucocorticoid (GC)-induced osteoporosis (GIO) occurs in patients undergoing therapeutic intervention for inflammatory disorders such as rheumatoid arthritis and lupus. The effect of long-term GC administration on bone turnover was investigated in two frequently used mouse strains; C57BL/6 and CD1 in order to assess the influence of genetic background.GIO was induced in 12 weeks old female C57BL/6 and CD1 mice by s.c. insertion of long-term (60 days) rel...

ba0003pp220 | Osteoporosis: evaluation and imaging | ECTS2014

The fracture outpatient clinic: what is the additional value of vertebral assessments and which individuals should be more actively recruited?

Muilwijk Carolien , Lips Paul , Lems Willem , Bultink Irene , den Heijer Martin , de Jongh Renate

Fracture outpatient (FO) clinics aim to identify individuals at high fracture risk. Identification of individuals at high fracture risk has been improved since the introduction of vertebral fracture assessment (VFA). Unfortunately, participation rates in FO clinics are often low.The aim of this study is to i) assess the contributory value of VFA in addition to BMD measurements in identifying individuals with high fracture risk; ii) assess characteristics...

ba0003pp221 | Osteoporosis: evaluation and imaging | ECTS2014

Comparison of diagnostic strategies to detect prevalent vertebral fracture for adults over age 50: use of vertebral fracture assessment or spine radiography

Kim Deog-Yoon , Oh Sung-Hee , Ahn Jeonghoon , Lee Young Eun , Lee Yu Kyung , Hwang Jin-Seub , Yoo Na Eun , Lee Joo-Hyun , Pyo Junhee , Kim Dam , Choi Yun Young , Bae Sang-Cheol , Sung Yoon-Kyoung

Background: The prevalent vertebral fracture (VF) is a risk factor for future VF, which can be decreased with drug therapy. However, most VFs are not recognized clinically. VFA by DXA and spine X-ray can be performed to detect these prevalent VFs.Objectives: This study aimed to estimate the costs, effectiveness, and radiation exposure of VF diagnostic strategies.Methods: Markov model over a 10-year period was used to calculate the ...

ba0003pp222 | Osteoporosis: evaluation and imaging | ECTS2014

Association of CT-based finite element estimates of femur strength with fracture status in three clinical studies on post-menopausal women

Schileo Enrico , Falcinelli Cristina , Balistreri Luca , Henys Petr , Baruffaldi Fabio , Sigurdsson Sigurdur , Gudnason Vilmundur , Boutroy Stephanie , Taddei Fulvia

Introduction: The first clinical applications of FE-strength estimates to classify osteoporotic fractures showed inhomogeneous results. We developed a FE model that correlated well with femur strength in-vitro (R2=0.9, 14 femurs). This work aims to verify if our model can classify osteoporotic fractures in three case-control studies: a retrospective and a prospective study on proximal femur fracture, and a retrospective study on prevalent ...

ba0003pp223 | Osteoporosis: evaluation and imaging | ECTS2014

Bone mineral density and bone turnover markers in patients with thyroid cancer and L-T4 suppressive therapy after 25 years of follow-up

de Mingo Dominguez Maria Luisa , Iglesias Sonsoles Guadalix , Alvarez Maria Begona Lopez , Diaz-Guerra Guillermo Martinez , Carranza Federico Hawkins

Background: Patients with differentiated thyroid cancer (DTC) are treated with L-thyroxine (L-T4) in relatively hight doses to suppress endogenous TSH levels. Very long-term effect of thyroid hormones supplementation on bone are controversial.Objetive: To study the possible negative effects on bone mineral density (BMD) and bone markers in DTC patients followed in our center.Methods: A 46 po...

ba0003pp224 | Osteoporosis: evaluation and imaging | ECTS2014

Discordance between bone mineral density and speed of sound measures of bone: the Canadian Multicentre Osteoporosis study

Olszynski Wojciech , Hanley David , Brown Jacques , Davison Kenneth , Adachi Jonathan

The objective of this investigation was to compare bone mineral density (BMD) attained from dual-energy X-ray DXA with speed of sound (SOS) data attained from a Beam-Med Omnisense multisite quantitative ultrasound (mQUS) in a large sample of randomly-selected community-based individuals from the Canadian Multicentre Osteoporosis Study (CaMOS). A total of 1177 men and 2949 women were assessed with mQUS at the distal radius, tibia, and phalanx sites as part of the Canadian Multi...

ba0003pp225 | Osteoporosis: evaluation and imaging | ECTS2014

Utilizing bisphosphonate binding kinetics and soft tissue-derived input functions to differentiate changes in long bone and vertebra bone metabolism using in vivo fluorescent molecular tomography

Tower Robert J , Muller Marc , Will Olga , Tiwari Sanjay , Gluer Claus C , Campbell Graeme M

Bone resorption and formation occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance, including osteoporosis and skeletal metastases. In the case of metastases, the uncoupling of resorption and formation activities contributes to disseminated tumor cells homing to the bone and to tumor growth within the bone in highly localized regions. Therefore, a site-specific marker of bone...

ba0003pp226 | Osteoporosis: evaluation and imaging | ECTS2014

Combining BINDEX and FRAX in treatment decision pathway for osteoporosis

Karjalainen Janne , Riekkinen Ossi , Kroger Heikki

Objective: According to National Osteoporosis Foundation (NOF) guidelines, treatment is recommended for osteoporotic patients and patients with osteopenia and high fracture probability (FRAX with BMD over 3% for hip and/or over 20% for other fractures). In this study, a pocket size pulse-echo (PE) ultrasound (US) device and FRAX with BMI is used in treatment pathway analysis and compared to NOF guidelines.Materials and methods: Elderly Caucasian woman (<...

ba0003pp227 | Osteoporosis: evaluation and imaging | ECTS2014

New point of care method for osteoporosis diagnostics in us

Karjalainen Janne , Riekkinen Ossi , Schousboe John

Objective: Currently, majority of the osteoporotic patients are not diagnosed i) a new ultrasound based device (Bindex) has been recently introduced for osteoporosis (OP) screening and diagnostics at primary healthcare ii) Bindex measures cortical thickness and determines parameter called density index (DI). Thresholds for DI in OP assessment have been determined in Finnish-Caucasian (F-C) population (n=448) along the International Society of Clinical Densitometry (IS...

ba0003pp228 | Osteoporosis: evaluation and imaging | ECTS2014

Changes of health-related quality of life 36 months after vertebral and distal forearm fracture: results from Icuros in Lithuania

Tamulaitiene Marija , Sinkeviciene Violeta , Kalibatiene Danute , Borgstrom Fredrik , Alekna Vidmantas

Objective: To evaluate the changes of health-related quality of life (HRQoL) 36 months after fracture in patients from Lithuania following vertebral or forearm fractures.Material and methods: Patients aged 50 years and older, with low energy trauma clinical vertebral fracture (VFx) or distal forearm fracture (FFx), enrolled and observed for 18 months in the International Costs and Utilities Related to Osteoporotic fractures Study (ICUROS) in Lithuania, w...

ba0003pp229 | Osteoporosis: evaluation and imaging | ECTS2014

Assessment of the possible use of the Austrian model of frax algorithm to predict fragility fracture risk factors in Ukrainian women

Povoroznyuk Vladyslav , Grygoryeva Nataliia

In the recent years, worldwide the FRAX algorithm is used more extensively to estimate the risk of fragility fractures. Since 2009, the Ukrainian Scientific Medical Centre on Osteoporosis has been extensively using the FRAX algorithm to estimate the fragility fracture risk.The aim of the study was to establish the normative data for the Austrian model of FRAX algorithm. We examined 3405 women aged 40–89. For the statistical analysis of results the S...

ba0003pp230 | Osteoporosis: evaluation and imaging | ECTS2014

Combination of spine TBS and clinical risk factors (CRF) can be used to detect women with osteoporotic fracture: a US study

Leib Edward , Lamy Olivier , Winzenrieth Renaud , Hans Didier

BMD alone is not sufficient to predict the fracture risk for an individual. Others parameters, such as microarchitecture play a key role in bone fragility. Several cross-sectional studies have shown the ability of TBS to discriminate fractured from healthy subjects in European populations. The aim of our study is to assess the ability of TBS, evaluated at the lumbar spine, to discriminate subjects with and without fracture in a large white US population....

ba0003pp231 | Osteoporosis: evaluation and imaging | ECTS2014

The impact of physical activity on estimated bone stiffness as assessed by multisite quantitative ultrasound: the Canadian Multicentre Osteoporosis study

Brown Jacques , Adachi Jonathan , Hanley David , Davison Kenneth , Olszynski Wojciech

This investigation sought to assess the relationship between physical activity (PA) and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halifax and...

ba0003pp232 | Osteoporosis: evaluation and imaging | ECTS2014

Serum creatinine profiles in hip fracture patients, an observational study

Frankland Stuart , Gupta Abhaya

Introduction: Kidney dysfunction is common in the elderly and has been proven to have an association with increased hip fracture incidence. Acute dysfunction may also delay surgery. Serum creatinine, a product of metabolised muscle tissue is a marker used to determine changes in renal function.Objective: To assess the renal function of hip fracture patients throughout their hospital stay using serum creatinine as the marker of renal function.<p class...

ba0003pp233 | Osteoporosis: evaluation and imaging | ECTS2014

aBMD at the hip measured by DXA overestimate cortical vBMD assesed by QCT scans

Amstrup Anne Kristine , Sikjaer Tanja , Mosekilde Leif , Rejnmark Lars

Background: DXA scan has for many years been gold standard when analyzing areal bone mineral density (aBMD) in osteoporotic patients. Risk of fractures increases as aBMD declines. However, although risk of fracture is highest in patients with osteoporosis, it is well known that the majority of fragility fractures actually occur in patients with osteopenia rather than osteoporosis. As aBMD is a projected two dimensional imaging technique it does not differentiate between cortic...

ba0003pp234 | Osteoporosis: evaluation and imaging | ECTS2014

Influence of age factor on the structural and functional organization of dentoalveolar system bone tissue in rats

Mazur Iryna , Gabal Viktoriia

Objective: The purpose of this study was to determine the impact of age on the ultrastructural, histological, biomechanical, and biochemical changes of bone tissue in rats.Methods: The study included 24 female rats of two age groups: Group A (Young) of 5-month old rats and Group B (Old) of 18-month old rats. Radiomorphometric assessment of the hydroxyapatite was used to investigate the ultrastructure of the alveolar bone tissue. Biomechanical and biochem...

ba0003pp235 | Osteoporosis: evaluation and imaging | ECTS2014

The impact of vitamin D and calcium intake on estimated bone stiffness as assessed by multisite quantitative ultrasound: the Canadian Multicentre Osteoporosis study

Hanley David , Brown Jacques , Adachi Jonathan , Davison Kenneth , Olszynski Wojciech

This investigation sought to assess the relationship between vitamin D and calcium intake and estimated bone stiffness as assessed by multisite quantitative ultrasound (mQUS) in a large cohort. A total of 1177 men and 2949 women were assessed with mQUS (Beam-Med Omnisense quantitative ultrasound; Isreal) at the distal radius, tibia, and phalanx sites as part of the Canadian Multicentre Osteoporosis Study (clinical sites included Saskatoon, Calgary, Hamilton, Quebec City, Halif...

ba0003pp236 | Osteoporosis: evaluation and imaging | ECTS2014

Improved assessment of vertebral cortex thickness by means of analytical deconvolution of radial bone mineral density distributions

Damm Timo , Pena Jaime , Bastgen Jan , Krause Matthias , Campbell Graeme , Barkmann Reinhard , Gluer Claus-Christian

New treatment agents against osteoporosis may not only lead to an improved trabecular structure, but can probably also strengthen the cortex. To assess this treatment effects by means of QCT, one has to deal with significant partial volume effects observing this very thin, but compact structure. A new method for cortical thickness estimation has been developed using an analytical deconvolution approach. After estimating the point-spread-function (PSF) of a scanner/kernel combi...

ba0003pp237 | Osteoporosis: evaluation and imaging | ECTS2014

Reference intervals for bone turnover markers in Spanish premenopausal women

Guanabens Nuria , Filella Xavier , Monegal Ana , Gomez-Vaquero Carmen , Bonet Maria , Buquet Dolors , Casado Enrique , Cerda Dacia , Erra Alba , Martinez Silvia , Montala Nuria , Pitarch Concepcion , Kanterewickz Eduardo , Sala Miquel , Suris Xavier , Torres Ferran , de Reumatoloia Lab Oscat Study Group Societat Catalana

Background and aims: Bone turnover markers (BTMs) are used in clinical practice for assessing patients with osteoporosis and their treatment. In Spain it is necessary to fine-tune the reference intervals, since they were established years ago in a low number of individuals. The aims of this study were to establish robust reference intervals for BTMs in healthy young premenopausal Spanish women and to investigate the factors influencing BTMs.Methods: 185 ...

ba0003pp238 | Osteoporosis: evaluation and imaging | ECTS2014

Correlation between localized femoral BMD T-scores and fractures site of hip, and evaluation of the sensitive of FRAX probability in hip fracture patients

Moon Kyoung Ho , Hong Taek Ho

Objection: We compared T-scores of each femoral neck and trochanteric area in the neck fracture patients (NFP) and intertrochanteric fracture patients (IFP). Our hypothesis is that T-score of neck portion in NFP is lower than T-score of neck portion in IFP, and vice versa. We evaluate how FRAX probability is meaningful and sensitive in hip fracture patients.Meterials and methods: From April, 2003 to September, 2012, 18...

ba0003pp239 | Osteoporosis: evaluation and imaging | ECTS2014

Impact of metal artefacts in QCT of the hip caused by a contralateral Gamma type nail: an ex vivo study

Engelke Klaus , Bouler Nicolas , Fuerst Oleg Museyko , Parratte Sebastien , Fuerst Thomas , Pion Francois-Xavier , Champsaur Pierre , Genant Harry , Corroller Thomas Le

Introduction: Gamma type nails are routinely used for the fixation of intertrochanteric fractures of the proximal femur. QCT at the hip is an advanced method that is increasingly being used to estimate BMD and determine the future fracture risk. Yet, implants cause metal artefacts (MA) in CT images, even at the contralateral side due to the high absorption of metal, which may impair BMD accuracy.Methods: Three human cadavers were scanned first without an...

ba0003pp240 | Osteoporosis: evaluation and imaging | ECTS2014

Glucocorticoids aggravate reduction in mineral and lean mass in active juvenile idiopathic arthritis

Stepan Jan , Maresova Kristyna Brabnikova , Jarosova Katerina , Pavelka Karel

The study is aimed to evaluate body composition and bone status in adult patients with active juvenile idiopathic arthritis (JIA) untreated with tumor necrosis factor α inhibitors. Adult patients (12 males and 19 females) with JIA and 84 healthy age- and gender- matched controls were enrolled into the study. Body composition and areal bone mineral density (aBMD) at the lumbar spine, proximal femur, femoral neck, distal radius and total body were assessed using dual energy...

ba0003pp241 | Osteoporosis: evaluation and imaging | ECTS2014

Peripheral densitometry in the assessment of fracture risk in adults with cerebral palsy

Radosław Gut , Mirosław Jabłoński , Marian Jędrych , Karolina Turżańska

A clinical and densitometric study was performed in the group of 62 adults with cerebral palsy (CP) under institutionalized care in the district of Przemyśl (Southern Poland), 12 of whom had the history of 15 radiologically confirmed non-phalangeal limb fractures. The study assessed correlation between the prevalence of fractures and age, body mass, locomotor abilities determined by Gross Motor Function Classification System (GMFCS), presence of epilepsy, antiepileptic dr...

ba0003pp242 | Osteoporosis: evaluation and imaging | ECTS2014

A systematic review of diagnostic accuracy of VFA using DXA in people aged over 50

Kim Deog-Yoon , Lee Yu Kyung , YoungEun Lee , Oh Sung-Hee , Hwang Jin-Seub , Kim Jinhee , Lee Joo-Hyun , Pyo Junhee , Kim Dam , Choi Yun Young , Bae Sang-Cheol , Sung Yoon-Kyoung

Objective: The postmenopausal women and elderly men have a big burden for osteoporosis related vertebral fracture and the frequency of clinically unrecognized vertebral fracture is known to be increasing. Vertebral Fracture Assessment (VFA) using DXA is a convenient and safe method to patients together with bone density test and is reported to be proper as a screening method to prevent additional vertebral fracture as diagnosing the vertebral fracture with unrecognized symptom...

ba0003pp243 | Osteoporosis: evaluation and imaging | ECTS2014

Trabecular bone score, bone mineral density and body composistion in men of different ages

Povoroznyuk Vladyslav , Musiienko Anna , Povoroznyuk Roksolana , Dzerovych Nataliia , Hans Didier

The aim of this study was to evaluate the trabecular bone score (TBS), bone mineral density (BMD) and body composition in men of various ages.Materials and methods: 300 men aged 40–87 years (mean age – 60.5±0.6 years; mean height – 1.61±0.003 m; mean weight – 84.1±0.9 kg) were examined. The patients were divided into the following age-dependent groups: 40–49 years (n=52), 50–59 years (n=90), ...

ba0003pp244 | Osteoporosis: evaluation and imaging | ECTS2014

Trabecular bone score, bone mineral density and body composistion in women of different ages

Povoroznyuk Vladyslav , Dzerovych Nataliia , Povoroznyuk Roksolana , Musiienko Anna , Hans Didier

The aim of this study was to evaluate the trabecular bone score (TBS), bone mineral density (BMD) and body composition in women of various ages.Materials and methods: 494 women aged 41–89 years (mean age, 63.6±0.4 years; mean height, 1.61±0.003 m; and mean weight, 74.0±0.6 kg) were examined. The patients were divided into the following age-dependent groups: 40–49 years (n=35), 50–59 years (n=130), 60–6...

ba0003pp245 | Osteoporosis: evaluation and imaging | ECTS2014

Prevalence of co-morbid conditions among fracture neck of femur patients in an acute hip unit

Siddarth K V , Karim Rehmat , Gupta Abhaya

Objective: To assess the prevalence of co-morbidities in fracture neck of femur patients.Methodology: Study design: Retrospective cohort study.Setting: District General Hospital in United Kingdom.Study subject: a total of 75 patients with fracture neck of femur from 2012 to 2013 were ascertained for any associated co-morbid conditions by case note study.Results: Out of 75 patients, 61 (...

ba0003pp246 | Osteoporosis: evaluation and imaging | ECTS2014

Do osteophytes protect femoral neck against fracture in osteoarthritis?

Bakides Sofoclis , Sakellariadis George , Charamis Angelos , Drivas Kiriakos , Ververeli Charilila-Loukia , Zakaki Semiramis , Kapagiannis Vasileios , Papageorgiou George

Introduction: The FRAX tool can be used to assess absolute fracture risk, but the majority of treatment decisions are still based on measurements by DEXA. In remote rural Greek areas, after the socioeconomy crisis, access to the nearest DEXA facility became more difficult.Purpose: Role of combined QUS and FRAX in the identification of low risk patients who do not require DEXA applying a FRAX threshold of 4% for the 10-year major osteoporotic fracture pro...

ba0003pp247 | Osteoporosis: evaluation and imaging | ECTS2014

Evaluation of bone mineral density at the inhabitants of Karelia

Marusenko Irina , Pashkova Inga , Polskaya Irina , Vezikova Natalia

Age is one of the most important factors that influence bone condition. At the age of 40–45 years for women (F) and 50 years for men (M) processes of bone formation and resorption are balanced, then bone resorption predominates.We examined 103 M (20–78 years) and 360 F (20–87 years), residing in the Republic of Karelia. Densitometry was performed for all patients to assess age-related changes in bone mineral density (BMD) at the lumbar spi...

ba0003pp248 | Osteoporosis: evaluation and imaging | ECTS2014

Effect of minodronate on vertebral bone microarchitecture in vivo assessed by computed tomography

Mawatari Taro , Ohishi Masanobu , Iwamoto Yukihide

Minodronate has been reported to increase bone mineral density (BMD) and reduce fracture risk. The purpose of this study was to clarify the effect of minodronate on the three-dimensional vertebral microarchitecture in vivo.Minodronate-treated osteoporosis female patients (n=9) and non-treated age-matched historical control (n=5) were retrospectively evaluated. After areal BMD (aBMD) evaluation by DXA, 3rd lumbar spine was scann...

ba0003pp249 | Osteoporosis: evaluation and imaging | ECTS2014

Prevalence of post-operative medical and surgical complications among fracture neck of femur patients in an acute hip unit

Karim Rehmat , Siddarth K V , Gupta Abhaya

Objective: To assess the prevalence of post-operative medical and surgical complications among fracture neck of femur patients.Method: Study design: retrospective cohort study.Setting: District General Hospital in UK.Study subject: a total of 75 patients with fracture neck of femur from 2012 to 2013 were ascertained for any post-operative complications by case note study.Results: Out of...

ba0003pp250 | Osteoporosis: evaluation and imaging | ECTS2014

Vitamin D levels in male patients with systemic lupus erythematosus

Vergara Cristina , Martinez-Ferrer Angels , Vicens Elvira , Valls Elia , Oller Jose , De la Morena Isabel , Ybanez Desamparados , Alegre Juan Jose

Introduction: Although systemic lupus erythematosus (SLE) has traditionally been considered a disease of women, men may also be afected. Male osteoporosis is increasingly recognised. Several studies have reported that mean bone mineral density is significantly reduced in SLE women patients and most of them have low levels of vitamin D. The aim of our study is to analize this situation in men.Objectives: Determine 25-hydroxyvitamin-D (25OHD) serum concent...

ba0003pp251 | Osteoporosis: evaluation and imaging | ECTS2014

The ability of quantitative ultrasound variables to identify osteoporosis in various regions of interest in female corticosteroid users

Sindel Dilsad , Ketenci Aysegul , Yaliman Ayse , Aydin Tugba , Koseoglu Pinar Kursuz , Oral Aydan

The objective of this study was to evaluate the ability of various quantitative ultrasound variables to discriminate osteoporotic female corticosteroid users. Thirty-two women aged between 26 and 79 years who have been receiving corticosteroids equivalent to a minimum of 5 mg daily prednisolone for more than 3 months underwent bone mineral density (BMD) measurements at the lumbar spine, hip, and one-third radius (33% radius) using dual-energy X-ray absorptiometry (DXA). Acoust...

ba0003pp252 | Osteoporosis: evaluation and imaging | ECTS2014

The development of a mathematical model to predict the time to osteoporosis using DEXA scanning

Scully Paul , Peters Catherine , Carew Sheila , Sheehy Tina , Costello Aine , Connor Margaret O , Lyons Declan

Background: Dual-energy X-ray absorptiometry (DEXA) is the gold standard used for measuring bone mineral density and such readings are currently used to predict osteoporosis and osteoporotic fractures. However, no similar prediction model has been developed to identify the age that a patient will become osteoporotic based on DEXA scanning.Objective: The aim of this study was to develop a mathematical model to determine the TTO based on two or more DEXA s...

ba0003pp253 | Osteoporosis: evaluation and imaging | ECTS2014

Bone mass in HIV male patients undergoing antiretroviral therapy

Moro-Alvarez Maria-Jesus , Ryan-Murua Pablo , Troya-Garcia Jesus , Solis-Villa Francisco-Javier , Villa-Azpeitia-Arman Francisco-Javier

Multiple factors of risk have been described to the osteoporosis (OSP) and fractures in people infected by human immunodeficiency virus (HIV). Antiretroviral treatment has changed the vital prognosis of these patients, nevertheless seems that antiretroviral treatments can cause a greater loss of bone mineral density (BMD). Experts support the use of densitometry screening for HIV-infected postmenopausal women and men older than 50 years.Objectives: To ev...

ba0003pp254 | Osteoporosis: evaluation and imaging | ECTS2014

Ten-year absolute fragility fracture risk and central DXA assessment: does hypovitaminosis D matter in menopausal women?

Carsote Mara , Radoi Valentin , Dusceac Roxana , Geleriu Andreea , Mihai Alexandra , Paun Diana , Miulescu Rucsandra Danciulescu , Poiana Catalina

Introduction: The FRAX model is a new method to assess fracture risk and this aspect is important in menopause. The DXA is still the golden standard but the relationship between these two instruments is complex.Aim: We correlate the 10-year absolute fracture risk of hip (10-yH) and major fractures (10-yM) based on FRAX with or without bone mineral density (BMD) with lumbar DXA in menopause women, and we use a statistical model to find out whether the vit...

ba0003pp255 | Osteoporosis: evaluation and imaging | ECTS2014

Dynamic changes in bone marrow adiposity during the menstrual cycle

Veldhuis-Vlug Annegreet , Limonard Eelkje , van Dussen Laura , Runge Jurgen , Tanck Michael , Endert Erik , Heijboer Annemieke , Fliers Eric , Hollak Carla , Akkerman Erik , Bisschop Peter

Background: Bone marrow (BM) adiposity is inversely related to bone mineral density and increases with ageing and menopause. We previously observed that the variation in BM fat fraction was more pronounced in premenopausal women compared to men and postmenopausal women. We hypothesized that the variation in BM fat fraction in premenopausal women is associated with hormonal variations during the menstrual cycle.Objective: To investigate the dynamic change...