Objectives: This study aimed to evaluate detailed bone profiles during puberty for Chinese adolescents in Hong Kong using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy x-ray absorptiometry (DXA).
Methods: 333 healthy girls and 231 healthy boys (1216-years-old) were recruited from secondary schools. Areal bone mineral density (aBMD) of bilateral femoral necks were measured by DXA while bone quality parameters were measured by HR-pQCT at the non-dominant distal radius. Maturity was assessed by Tanner staging.
Results: While a general increasing trend in bone density across puberty was found in girls, no difference on aBMD and vBMD between Tanner 3 and 4 was noted in boys. aBMD were numerically higher in boys at Tanner 13 while the reverse was noted at Tanner 45 with the difference reaching statistical significance at Tanner 4 (Default 1). Trabecular vBMD was higher in boys whereas girls had higher cortical and total vBMD especially at Tanner 45. Total area, cortical perimeter and trabecular area were higher in boys than girls across all Tanner stages. In contrast, cortical area and thickness were higher in girls especially at Tanner 45. Trabecular bone volume fraction and number were higher in boys while trabecular separation was higher in girls at Tanner 35.
Conclusion: There were differences on bone quality and density profiles across puberty between genders. A general increasing trend in aBMD and vBMD was only found in girls. Gender differences in bone parameters at the cortical and trabecular compartment were notably detected. Whether these were due to discrepancy in linear growth that outpaces mineral accretion in boys and whether estrogenic effect on endosteal apposition was responsible for these findings warrant further studies.
The project was supported by General Research Fund (468411, 468809).
Disclosure: The authors declared no competing interests.
Figure 1 Dominant femoral neck aBMD in chinese boys and girls across puberty.
27 - 30 Jun 2015