Bone Abstracts (2016) 5 P427 | DOI: 10.1530/boneabs.5.P427

Insulin resistance independently had the negative association with the bone mineral density in Korean young women

Woong Choi

Hanyang University Hospital, Seoul, Republic of Korea.

The relationships between insulin resistance and BMD are not clear. Therefore, we conducted a cross-sectional study to examine the relationship between insulin resistance and BMD among Korean young adult population. This study is based on the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2010. BMD and body composition were measured by DXA method. Insulin resistances were obtained by HOMA-IR equation. The relationship between BMD and HOMA-IR were analyzed with multiple regression models, which were adjusted with age, body weight, alcohol drink, exercise level and 25(OH) vitamin D level.

We analyzed 3686 persons (men: 1750, women: 1936) who were aged between 20 and 39 years old. HOMA-IR Showed positive correlations with lumbar BMD and femur BMD in men and all BMD in women. However we adjusted with age body weight, alcohol drink, exercise level and 25(OH) vitamin D level, insulin resistance had negative relationship with Lumbar BMD (B=−0.123, P<0.001), femur neck BMD (B=−0.057, P=0.01).

In this study, BMD were decreased with the increase of insulin resistance in Korean young adult.

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