ECTS2016 Poster Presentations Cancer and bone: basic, translational and clinical (37 abstracts)
Increased zinc accumulation in mineralized osteosarcoma tissue
Mirjam Rauwolf 1 , Bernhard Pemmer 1 , Andreas Roschger 2, , Anna Turyanskaya 1 , Rolf Simon 4 , S. Lang 5 , S E Puchner 6 , Reinhard Windhager 6 , Klaus Klaushofer 2 , Peter Wobrauschek 1 , Jochen G Hofstaetter 7, , Paul Roschger 2 & Christina Streli 1
1TU Wien, Atominstitut, Vienna, Austria; 2Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna, Austria; 3Department of Biomaterials, Max Planck Institute of Colloids and Interfaces, Potsdam, Germany; 4Karlsruhe Institute of Technology (KIT), ANKA synchrotron radiation source, Karlsruhe, Germany; 5Department of Pathology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria; 6Department of Orthopaedic Surgery, Vienna General Hospital, Medical University of Vienna, Vienna, Austria; 7Orthopaedic Hospital Vienna-Speising, Vienna, Austria.
Abnormal tissue levels of certain trace elements such as Zinc (Zn) were reported in various types of cancer. Little is known about the role of Zn in osteosarcoma.
Using confocal synchrotron radiation micro X-ray fluorescence analysis, we characterized the spatial distribution of Zn in high-grade (G3) sclerosing osteosarcoma of nine patients (4 f/5 m; 7 knee/1 humerus/1 femur) following chemotherapy and wide surgical resection. The study was done in accordance with the Helsinki Declaration.
Zn levels in mineralized osteosarcoma tissue were compared to levels in adjacent normal tissue. Quantitative backscattered electron imaging (qBEI) as well as histological examinations were also performed. On average, the ratio of medians of Zn count rates (normalized to calcium) in mineralized tumor tissue was about 6 times higher than in normal tissue. There was no difference in Zn levels between tumor fraction areas with a low and a high fraction of mineralized tissue, which were clearly depicted using qBEI. Moreover, we found no correlation between the Zn values and the type of tumor regression according to the Salzer-Kuntschik grading. The underlying mechanism of Zn accumulation remains unclear. Given the emerging data on the role of trace elements in other types of cancer, our novel results warrant further studies on the role of trace elements in bone cancer.
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Bone Abstracts
ISSN 2052-1219 (online)
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