ECTS2016 Poster Presentations Energy metabolism and bone, fat and bone (11 abstracts)
Changes in circulating osteocalcin concentration in overweight and obese adult women having normal glucose and hemoglobin A1c levels
Susana Zeni 1 , Liliana Zago 2 , Carlos A Gonzalez Infantino 4 , Lugones Carlos 1 , Graciela Brito 3, , Watson Dana 3 & Oliveri Beatriz 3
1Laboratorio de Enfermedades Metabólicas Óseas, Hospital de Clínicas, Instituto de Inmunología, Genética y Metabolismo (INIGEM) CONICET- UBA, Buenos Aires, Argentina; 2Cátedra de Nutrición. Facultad de Farmacia y Bioquímica UBA, Buenos Aires, Armenia; 3Catedra de Nutrición Universidad Nacional de la Matanza., Buenos Aires, Argentina; 4Servicio de Nutricion. Hosp. de Clinicas. Fac. de Medicina. UBA, Buenos Aires, Argentina.
Osteocalcin (OC) plays crucial roles in glucose homeostasis. OC level in the circulation appears to be associated with glucose and fat metabolism – Although still it remains controversial if it are the levels of total OC and/or undercarboxilated OC (ucOC) which present such association. The present study evaluated the levels of ucOC, total OC, leptin and insulin, in 226 overweight or obese (degree I and II) adult non-diabetic women, having levels of glucose (80–110 mg/dl) and hemoglobin A1c (HbA1c <5.7%) within normal range. Women, aged 20–86 years were divided in four groups according to their menopausal status: premenopause (PreM) (<45 ys); peri-menopause (periM) (45 and <50), early menopause (EM) (50–65 ys) and late menopause (LM) (>65 ys). Body weight and height were used to calculate BMI score for determining overweight and the degree of obesity. Calcium intake (CaI) was estimated by a semi-quantitative food frequency questionnaire. Serum levels of glucose, cholesterol, triglycerides, HbA1c were carried out automatically using standard laboratory methods. Enzyme immunoassays were used for serum ucOC (ng/ml), OC (ng/ml), leptin (ng/ml), insulin (uUI/l) levels determination. Levels of 25hydroxyvitamin D (25OHD) (ng/ml) were assayed by a competitive protein-binding method. Some results (mean±S.D.) are shown in the table.
Irrespectively of the mean age, the levels of ucOC, insulin and leptin increased as the BMI increased while OC levels decrease in degree II obese women.
For a same BMI, ucOC showed a tendency to increase while OC did not change with increasing age.
| Menopausal status | Ucoc | OC | Insulin | Leptin |
| Overweight | ||||
| preM | 1.96±1.08 | 29.9±2.7 | 9.2±3.9 | 11.1±3.3 |
| periM | 2.75±1.22 | 31.3±7.3 | 5.8±1.1 | 9.7±1.7 |
| EM | 2.20±1.34 | 35.1±5.3 | 6.1±1.7 | 9.7±1.1 |
| LM | 3.81±1.89 | 29.1±4.6 | 5.2±1.4 | 7.3±2.5 |
| Degree I obesity | ||||
| preM | 2.21±0.98 | 30.0±2.21 | 11.7±1.9 | 17.8±4.3 |
| periM | 2.93±0.78 | 31.6±5.9 | 11.8±2.4 | 18.2±2.4 |
| EM | 3.41±096 | 37.1±9.5 | 9.8±1.5 | 20.9±5.2 |
| LM | 3.81±0.96 | 24.9±4.5 | 11.8±3.2 | 17.7±6.3 |
| Degree II obesity | ||||
| preM | 4.08±0.41 | 19.9±8.6 | 16.0±6.4 | 43.7±8.8 |
| periM | 4.50±0.22 | 21.6±11.3 | 12.5±2.5 | 25.3±6.14 |
| EM | 4.11±0.6 | 21.7±4.7 | 10.3±1.7 | 27.1±4.4 |
| LM | 5.52±1.7 | 26.9±5.2 | 12.8±1.8 | 31.0±8.2 |
Conclusions: Although further studies are needed, the present study showed that the levels of ucOC and not the levels of total OC are BMI-dependent in normoglucemic non-diabetic women. Grants: PROINCE E-006 (UNLaM 2015–2016) and CONICET.
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