Bone Abstracts (2016) 5 P295 | DOI: 10.1530/boneabs.5.P295

Risk factors for subsequent vertebral compression fracture following osteoporotic compression fracture

Sung Soo Kim1, Jin Hwan Kim2, Jung Hoon Kim2, Byung Wan Choi1 & Dong Hyun Lee1


1Haeundae Paik Hospital, Busan, Republic of Korea; 2Ilsan Paik Hospital, Goyang, Republic of Korea.


Objectives: To evaluate risk factors of subsequent vertebral fracture following acute osteoporotic vertebral compression fracture.

Methods: As a multicenter retrospective study, we recruited 135 patients treated for acute osteoporotic compression fracture with available spine image taken at 1-year follow-up in three hospitals. The patients were divided into two groups according to occurrence of subsequent vertebral fracture. Two groups were analyzed with age, sex, bone mineral density, medical comorbidity, acute fracture level, presence of prior vertebral fracture, osteoporosis medication, treatment method.

Results: The new vertebral fractures were detected in 25 patients (19%) in total. With the univariate analysis, there were no significant differences between the two groups in age, sex, medical comorbidity, presence of prior vertebral fracture and acute fracture level. However in the group with subsequent vertebral fracture, more patients were treated by vertebroplasty or kyphoplasty and had femur neck T score ≤−2.5 and poor compliance of osteoporosis medication with significant difference (P<0.05). Using the multivariate analysis, it was found that subsequent vertebral fractures were significantly influenced by vertebroplasty or kyphoplasty (P=0.003, odds ratio=4.71) and femur neck T score ≤−2.5 (P=0.013, odds ratio=3.47).

Conclusions: The subsequent vertebral fractures were found in 19% at 1 year after the treatment of acute osteoporotic compression fracture. Risk factors for them were (1) vertebroplasty or kyphoplasty and (2) femur neck T-score ≤−2.5.

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