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Bone Abstracts (2016) 5 P39 | DOI: 10.1530/boneabs.5.P39

ECTS2016 Poster Presentations Bone biomechanics and quality (21 abstracts)

Depth and location dependence of subchondral trabecular structure across the tibia in human osteoarthritic knee versus normal knee: a micro-CT study

Hamid Bouhadoun 1 , Klaus Engelke 2 , Jean Denis Laredo 1, & Christine Chappard 1


1B2OA UMR 7052 CNRS Paris Diderot University, Paris, France; 2Institute of Medical Physics University of Erlangen-Nürnberg, Erlangen, Germany; 3Service de Radiologie Ostéo-Articulaire Hôpital Lariboisière, Paris, France.


Objective: To determine differences between osteoarthritic (OA) knees with normal knees for subchondral trabecular bone structure according to depth and location in the tibial plateau.

Methods: In a population of 30 cadaveric left knees (18 women and 12 men, mean age: 79.1 years±8.2, range: 63–90) the Kellgren-Lawrence (KL) score was determined from post mortem radiographs: OA=KL≧2 (n=6 women, n=5 men) and controls=KL ≤1.

After dissection, two vertical cores (7 mm in diameter) were extracted in the central region of the medial tibial plateau (S1) not covered by meniscus and peripheral (S2) fully covered by the meniscus. Each core was imaged with micro-CT (SkyScan 1172®) pixel size 10.23 μm. In the first 1–5 mm and the 6–10 mm beneath the subchondral bone plate: Bone Volume/Total Volume (BV/TV,%), Trabecular Number (Tb.N,1/mm), Trabecular Thickness (Tb.Th,mm), Trabecular Separation (Tb.Sp,mm), Degree of Anisotropy (DA), Structure Model Index (SMI) and Trabecular Bone Factor (Tb.Pf) were measured.

To investigate differences in trabecular bone structure between OA and controls, a separate analysis of covariance with age as covariate was performed for men and women separately.

Results: At 1-5mm, in G1 location for both men and women, Tb.N, Tb.Sp, Tb.Pf and SMI were significantly different (0.04<P< 0.001), for men BV/TV was also different (P=0.006) and for women DA (P=0.01). In G2 location for both men and women, BV/TV and Tb.N were significantly different (0.04<P<0.02). Tb.Sp and DA were also significantly different in women P=0.01 and P=0.03, respectively. At 6–10 mm, there was no difference of any parameters between OA and controls in both men and women.

Conclusions: We conclude that the impact of OA in subchondral bone was only present in the first 5mm beneath the subchondral plate with constantly found an increase of Tb.N, and in a lesser extend a greater connectivity, a more plate like structure and a decrease of anisotropy.

Volume 5

43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

European Calcified Tissue Society 

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