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Bone Abstracts (2016) 5 WSWS5.2 | DOI: 10.1530/boneabs.5.WS5.2

Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine. Isehara, Japan.


Various abnormalities of mineral metabolism develop in patients with chronic kidney disease (CKD), which are further modified by therapeutic modalities including renal replacement therapy. Although secondary hyperparathyroidism is the most popular abnormality, it has been well recognized that uremic patients show skeletal resistance to PTH at the same time. Thus, bone metabolism in CKD patients shows very complex clinical presentations. Bone fracture occurs more frequently in CKD patients than in general population, however, such a difference cannot be explained sufficiently either by high PTH level or by decreased bone mineral density. We analyzed bones of CKD model rats, which showed abnormal mechanical properties despite comparable bone mineral density. We have shown by confocal Raman spectroscopy analysis that bone of these CKD rats contained more non-physiological collagen crosslink, abnormal crystallinity, and abnormal apatite orientation. Because these abnormalities were ameliorated by AST-120 treatment, uremic toxins may play important roles in deranged bone quality in CKD.

Volume 5

43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

European Calcified Tissue Society 

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