Searchable abstracts of presentations at key conferences on calcified tissues
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43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

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Muscle and Bone Session

Muscle & Bone

ba0005mb1.7 | Muscle & Bone | ECTS2016

Translational studies on muscle hypertrophy and function

Gromada Jesper

Loss of skeletal muscle mass and function in humans is associated with significant morbidity and mortality. The role of myostatin as a key negative regulator of skeletal muscle mass and function has supported the concept that inactivation of myostatin could be a useful approach for treating muscle wasting diseases. The human monoclonal antibody REGN1033 is a specific and potent myostatin antagonist. Treatment of mice with REGN1033 increased muscle fiber size, muscle mass, and ...