Bone Abstracts

Objectives: Bone mineral density (BMD) in children is generally measured with dual energy X-ray absorptiometry (DXA). Digital X-ray Radiogrammetry (DXR) is a promising alternative technique, that uses BoneXpert software to measure cortical BMD on hand radiographs, expressed as bone health index (BHI). DXR is a cheap method, is easy to apply in every hospital and involves less ionizing radiation compared to DXA. We aim to compare DXR and DXA measurements for determining bone de...

Background: The Ketogenic Diet Treatment (KDT) is a well-established intervention for intractable childhood epilepsy and the first choice treatment for Gluccose-1-transporter-deficiency-syndrome and Pyruvate-dehydrogenase-complex deficiency. During long-term follow up of children treated with KDT an increased incidence of bone fractures has been found. However, the exact contribution of KDT to a decreased BMD remains unclear. Prophylactic supplementation with calcium and vitam...

Objectives: To elucidate the incidence and risk factors of skeletal toxicity in children with ALL treated with the dexamethasone-based DCOG-ALL9 protocol.Methods: Prospectively, the cumulative incidence of fractures was assessed in 672 patients and compared between different subgroups using the log-rank test. Serial measurements of bone mineral density of the lumbar spine (BMDLS) were performed in 399 ALL patients using dual energy X-ray absor...