Searchable abstracts of presentations at key conferences on calcified tissues

ba0001niw1 | (1) | ECTS2013

Genomics and proteomics as emerging technologies in bone research

Uitterlinden Andre G

The quantum leaps in scientific progress have frequently come from technological innovations, which can be referred to as the technology push. In the life-sciences this has been exemplified by the emergence of all kinds of ‘omics’ technologies reflecting the capacity to analyse complete and complex molecular mixtures in a hypothesis-free approach, also known as ‘fishing expeditions’ by more sceptical fellow scientists. Such approaches have been developed fo...

ba0001pp91 | Bone development/growth and fracture repair | ECTS2013

Pediatric differences in bone mineral density according to ethnic background in children: the Generation R Study

Medina-Gomez Carolina , Heppe Denise H M , Hofman Albert , Jaddoe Vincent , Uitterlinden Andre , Rivadeneira Fernando

Aim: Differences in fracture risk between ethnic groups have been documented. The basis for these differences is yet incomplete and the age at what ethnic differences appear is uncertain. Assessment of bone health in pediatric populations could bring insights on factors compromising bone accrual. We describe here differences in total body bone mineral density (TB-BMD) in a unique setting of children of the same age, measured with the same device (iDXA) different ethnic backgro...

ba0002oc3 | Epidemiology | ICCBH2013

Pediatric differences in bone mineral density according to ethnic background in children: The Generation R Study

Medina-Gomez Carolina , Heppe Denise , Hofman Albert , Uitterlinden Andre G , Jaddoe Vincent , Rivadeneira Fernando

Aim: Differences in fracture risk between ethnic groups have been documented. The basis for these differences is yet incomplete and the age at what ethnic differences appear is uncertain. Assessment of bone health in pediatric populations could bring insights on factors compromising bone accrual. We describe here differences in total body bone mineral density (TB-BMD) in a unique setting of children of the same age, measured with the same device (iDXA) different ethnic backgro...

ba0005p241 | Genetics and Epigenetics | ECTS2016

Identification of a novel locus on 2q13 of large effect size which predisposes to clinical vertebral fractures independently of BMD: the GEFOS consortium

Alonso Nerea , The Clinical Vertebral Fracture Consortium Nerea , Uitterlinden Andre , Rivadeneira Fernando , Ralston Stuart H

Vertebral fractures are the most common complication of osteoporosis, but little is known about the genetic determinants of susceptibility. Here we present the results of a genome wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with replication in 667 cases and 2105 controls. A locus tagged by a less frequent variant (rs10190845, A-allele MAF=0.05) was identified on chromosome 2q13 as a strong predictor of clinical verte...

ba0003oc4.3 | Genetics of bone disease | ECTS2014

Exome-chip meta-analysis identifies novel associations of coding variants in BSN and GLRA4 with lumbar spine BMD in 27 339 adults of European descent

Estrada Karol , Kiel Douglas , Uitterlinden Andre , Rivadeneira Fernando , Hsu Yi-Hsiang , for the exome-chip meta-analysis working group

In previous work we identified 63 common variants (MAF>5%) from 56 loci associated with BMD fully comprising non-coding regions of the genome. We hypothesized that genes may harbour both common and rare variants in the protein-coding regions may influence BMD variation. The availability of the ‘exome-chip’ with 235 933 protein-coding variants (non-synonymous, splice sites and stop-altering) provides a feasible way to identify low-frequency variants in exomes....

ba0003oc6.1 | Osteoporosis treatment and the effects of physical activity | ECTS2014

Sex differences in bone acquisition of pre-pubertal children are consequence of differential responsiveness to mechanical loading

Medina-Gomez Carolina , Heppe Denise H.M. , Kruithof Claudia J. , Hofman Albert , Uitterlinden Andre G. , Jaddoe Vincent V.W. , Rivadeneira Fernando

Aim: Lean mass is a strong determinant of bone structure, particularly during growth and development. We sought to determine if there are sex differences in bone acquisition in pre-pubertal children and the potential relation with skeletal loading.Methods: This study included 3602 children (50.7% girls) whose total body BMD and hip scans were measured on the same iDXA devise (GE-Lunar) at 6 years of age. Hip scans underwent hip structural analysis (HSA) ...

ba0006oc13 | (1) | ICCBH2017

Enterococccus faecium abundance in gut microbiome is associated with higher bone mineral density in school age children

Medina-Gomez Carolina , Radjabzadeh Djawad , Boer Cindy G. , Van Meurs Joyce , Kraaij Robert , Uitterlinden Andre G , Rivadeneira Fernando

Aim: Human gut microbiota is an important determinant of health and disease. Discoveries from recent microbiome studies have been postulated as actionable targets to treat malnutrition, diabetes, obesity among other conditions. The role of the gut microbiome on the development of the human musculoskeletal system is yet to be established. The aim of our study was to investigate the association between bacterial operational taxonomic units (OTUs) of the gut in relation to bone m...

ba0006oc15 | (1) | ICCBH2017

Fractures in school age children in relation to sex, ethnic background and bone mineral density: the generation R Study

Grgic Olja , Medina-Gomez Carolina , Trajanoska Katerina , Shevroja Enisa , Koromani Fjorda , Uitterlinden Andre , Jaddoe Vincent , Wolvius Eppo , Rivadeneira Fernando

Objectives: Previous studies indicate that about half of boys and one fourth of girls suffer a fracture before the age of 16 years. Similarly, children of European descent are more prone to fracture. Here we aimed to investigate at the population level the influence of sex, ethnic background and bone mineral density (BMD) on the occurrence of bone fractures in children of school age.Methods: This study (n=3,633 children with complete information...

ba0006p015 | (1) | ICCBH2017

Structural geometry of bones is prominently associated with risk of fracture in children

Medina-Gomez Carolina , Grgic Olja , Shevroja Enisa , Trajanoska Katerina , Uitterlinden Andre G , Jaddoe Vincent W , Beck Tom J , Rivadeneira Fernando

Background: Low total body BMD (TB-BMD) is an established risk factor for fractures in healthy children. However, bone strength depends not only on bone mass and density, but also on the structural geometry of bones. Hip structural analysis (HSA) is a technique applied on hip DXA scans to calculate several bone geometry parameters. The aim of our study was to evaluate other bone geometrical parameters that can constitute determinants of fracture risk. Specifically, we examined...