Non-pharmacologic approaches to preserve or increase BMD include whole body vibration (WBV). A meta-analysis and one-year randomized trial concluded that WBV has no effect on BMD in older women; however, previous trials were relatively brief and did not include a sham control group. Therefore, we conducted the Vibration to Improve Bone in Elderly Subjects (VIBES) trial, a randomized, sham-controlled trial of 10 min of daily WBV (0.3 g at 30 Hz) in seniors recruited from 16 independent living communities around Boston Massachusetts, USA. We randomized 174 men and women (89 active, 85 sham) with T-scores −1 to −2.5 who were not taking bone active drugs and had no diseases affecting the skeleton (mean age 82±7 years, range 65102). The trial was originally planned for 2 years, but was extended for a third year. Participants received calcium 1000 mg and vitamin D 800 IU. Shared intervention platforms were activated using radiofrequency ID cards providing electronic adherence monitoring. Sham platforms resembled the active platforms. In total, 61% of participants in the active arm and 73% in the sham arm completed 24 months. Of 29 individuals assigned to the active arm who agreed to a third year, 97% completed it; for the sham arm, 85% of 26 completed the third year. The primary outcomes measured by QCT, absolute changes in total femoral trabecular BMD, and in average mid-vertebral trabecular BMD of L1 and L2, were no different between active and sham arms (differences=0.0011 and 0.0003 g/cm3 respectively, all P values >0.2). Changes in biochemical markers of bone turnover (P1NP and sCTX) did not differ between groups (P=0.18 and P=0.97 respectively). Overall, mean adherence was 69%. In conclusion, this sham-controlled randomized trial of daily WBV in seniors of advanced age did not demonstrate evidence of beneficial effects on QCT BMD.
18 May 2013 - 22 May 2013