OP2026 Poster Presentations Original Research (32 abstracts)
Microarchitectural measurements of cortical and trabecular bone from digital tomosynthesis images of the hand: Preliminary results and future potential.
Sophie Coulson 1 , Karen Knapp 2 , Junning Chen 2 , Sascha Kranen 2 , Susannah Earl 3 , Luke Jones 3 , Sian Phillips 1 , Katy Knight 2 , Jingrui Hu 2 & Steve Wells 1
1Adaptix Ltd, Oxford, United Kingdom;2University of Exeter, Exeter, United Kingdom;3Royal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom
Background: Compact digital tomosynthesis (DT) represents an evolution in musculoskeletal imaging, combining many of the advantages of conventional radiography and computed tomography into a compact, low-dose, portable, point-of-care modality. DT enables greater visualisation of bone microstructure and avoids superimposition of bone. The aim of this study was to develop quantification algorithms for trabecular bone architecture, porosity, and cortical thickness.
Methods: 25 participants (17 females) with inflammatory arthritis were recruited for the first in human trial of the Adaptix Ortho350 (Adaptix Ltd, UK) under HRA and MHRA approvals (25/YH/0032 and CI/2025/0038/GB). Participants had bilateral hand imaging undertaken on the Adaptix Ortho350. Algorithms were developed to measure the cortical thickness (CT), with five regions of interest (ROIs) each for distal interphalangeal joints (DIP) and metacarpophalangeal joints (MCP), four ROIs for proximal interphalangeal joints (PIP). Each CT value was derived from the mean calculated value over five in-focus slices. 18 ROIs were selected for each hand over the MCP and PIP metaphyses. Each bone volume / total volume (BV/TV) is the mean of the BV/TV calculated for that region over five different in-focus slices. Data were analysed using unpaired t-tests for all cortical ROIs and BV/TV ROIs for those with 2 years duration of inflammatory arthritis compared to those with 2 years of disease presence.
Results:
| Age Mean ± SD | CT Mean ± SD | BV/TV Mean ± SD | |
| Males < 2y | 65.3 ± 10.9 | 0.341 ± 0.041 | 0.286 ± 0.021 |
| Males >2y | 62.5 ± 12.5 | 0.359 ± 0.054* | 0.284 ± 0.017 |
| Females <2y | 56.6 ± 13.0 | 0.316 ± 0.040 | 0.276 ± 0.022 |
| Females >2y | 67.2 ± 11.0 | 0.326 ± 0.383* | 0.273 ± 0.015* |
| * P 0.05 compared to 2 years disease duration. | |||
Conclusion: These results provide a proof of concept for quantitative bone architectural measurements from DT. However, due to the small number of participants, these results should be treated with a degree of caution. Further work is required to optimise the algorithms and to test in a larger group of participants.
Volume 8
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Bone Abstracts
ISSN 2052-1219 (online)
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