Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p9 | Arthritis and other joint diseases: translational and clinical | ECTS2016

Apolipoprotein E aggravates inflammation and bone destruction in murine antigen – induced arthritis

Ascone Giuliana , Ceglie Irene Di , de Munter Wouter , Walgreen Birgitte , Sloetjes Annet , van Lent Peter

Background and Objectives: Rheumatoid arthritis (RA) is a chronic disease characterized by severe bone destruction which has been associated with altered lipid metabolism. Apolipoprotein E (Apo E) is a lipoprotein mainly produced by macrophages. ApoE has been described as crucial in lipid metabolism but also as an important anti-inflammatory mediator regulating innate immunity and bone turnover. In the present study we investigated the role of Apo E in bone destruction during ...