Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p5 | Arthritis and other joint diseases: translational and clinical | ECTS2016

The effects of hydroxychloroquine on bone turnover

Both T , van der Eerden B C J , Koedam M , Zillikens M C , van Laar J A M , Dalm V A S H , van Leeuwen H P T M , van Hagen P M , van Daele P L A

Introduction: We recently showed that patients with primary Sjögren Syndrome (pSS) have significantly higher bone mineral density (BMD) in the lumbar spine and femoral neck compared with healthy controls. The majority of those patients (69%) were using hydroxychloroquine (HCQ), which may have favourable effects on BMD.Aim: To evaluate whether HCQ modulates human bone cells in vitro.Methods: Osteoblasts were differenti...

ba0006is11biog | (1) (1) | ICCBH2017

IS11

van Leeuwen Hans

Biographical DetailsHans van LeeuwenHans (J.P.T.M.) van Leeuwen studied biology in Amsterdam, and did his PhD study on the mechanism of action of PTH in Leiden, The Netherlands. Currently he is professor at the Erasmus University Medical Center in Rotterdam, The Netherlands, leading the research program on Calcium and Bone Metabolism. Main research ...

ba0001pp203 | Cell biology: osteoblasts and bone formation | ECTS2013

Connectivity Map-based discovery of novel compounds that induce osteoblast differentiation

Brum A M , van de Peppel J , van Kerkwijk A , Janssen M , Schreuders-Koedam M , Strini T , Eijken M , van Leeuwen J P T M , van der Eerden B C J

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. Little is currently known about what specific factors stimulate osteoblast differentiation from human mesenchymal stem cells (hMSCs). Therefore, the aim for this project is to determine novel factors and mechanisms involved in human bone production which can be targeted to treat osteoporosis, using gene expression profiling and bioinformati...

ba0002oc11 | Biology | ICCBH2013

Connectivity map-based discovery of novel compounds that induce osteoblast differentiation

Brum A M , de Peppel J van , van Kerkwijk A , Janssen M , Schreuders-Koedam M , Strini T , Eijken M , van Leeuwen J P T M , van der Eerden B C J

Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. Little is currently known about what specific factors stimulate osteoblast differentiation from human mesenchymal stem cells (hMSCs). Therefore, the aim for this project is to determine novel factors and mechanisms involved in human bone production which can be targeted to treat osteoporosis, using gene expression profiling and bioinformati...

ba0005p158 | Cell biology: osteoblasts and bone formation | ECTS2016

A single 2-day pulse of activin-A leads to a transient change in gene expression eventually followed by reduction in extracellular matrix mineralization

Baroncelli Marta , Drabek Ksenija , Eijken Marco , Peppel Jeroen van de , van Leeuwen Johannes

Activins belong to the transforming growth factor-β superfamily, and they regulate bone formation by controlling both osteoclast and osteoblast behaviour. We have previously shown that activin-A strongly inhibited matrix mineralization in osteoblast cultures, and that activin A-signalling was most effective before the onset of mineralization.The aim of this study was therefore to investigate how an early activin-A pulse affected osteoblast mineraliz...

ba0005p61 | Bone development/growth and fracture repair | ECTS2016

Advanced phase gestational jet lag reduces bone mass of adult offspring

van der Eerden Bram , Chaves Ines , Azimzadeh Pedram , Schreuders-Koedam Marijke , Reiss Irwin , van Leeuwen Johannes , van der Horst Gijsbertus

The mammalian circadian clock is tightly controlled by clock genes, which have been shown to regulate up to 20% of the transcriptome in any given tissue. Evidence is accumulating that light-modulation perpetually affects circadian clock performance. In accordance, shift work or chronic jet lag is associated with higher risk of disease later in life, including osteoporosis. In this study, we assessed whether gestational jet lag in mice reduces bone mass postnatally.<p class...

ba0005oc1.4 | Clinical trials and osteoporosis treatment | ECTS2016

Relationship between total hip (TH) BMD T-score and incidence of nonvertebral fracture (NVFX) with up to 10 years of Denosumab (Dmab) treatment

Ferrari S , Adami S , Brown J P , Cosman F , Czerwiński E , de Gregorio L H , Malouf J , Reginster J-Y , Daizadeh N S , Wang A , Wagman R B , Lewiecki E M

The relationship between BMD T-score and FX risk has not been established in patients receiving osteoporosis therapy. In the FREEDOM Extension study, continuous DMAb therapy for up to 10 years increased BMD levels with no therapeutic plateau at lumbar spine or TH [Bone et al, ASBMR 2015]. Such improvements would only be meaningful if associated with FX reductions. We investigated the relationship between TH BMD T-score and NVFX in women who received DMAb during FREEDOM and tho...

ba0006is11 | (1) (1) | ICCBH2017

IS11

van Leeuwen Hans

Abstract not submitted...

ba0003pp190 | Genetics | ECTS2014

Premature aging of bone is delayed by dietary restriction

van der Eerden Bram , Botter Sander , Reiling Erwin , Hoeijmakers Jan , Dolle Martijn , van Leeuwen Johannes

Loss of genomic maintenance contributes to aging, as exemplified by mutations in Ercc DNA repair proteins that lead to a plethora of progeroid syndromes of which some display accelerated bone loss. It is generally accepted that dietary restriction (DR) increases life span and improves organ function. We therefore assessed the impact of DR on life span and bone mass in WT and bona fide prematurely aging hypomorphic Ercc-deficient mice (Ercc1−/Δ).<...