ba0003pp150 | Cell biology: osteoblasts and bone formation | ECTS2014
, Siersbaek Majken
, Dobbelstein Matthias
, Kassen Moustapha
Protein kinases are an important class of regulatory elements and pharmacological targets for treatment of a number of diseases including cancer, heart and lung diseases. However, their role in regulation of the skeletal (mesenchymal) stem cell (MSC) functions and bone formation is not fully understood. Thus, we performed functional screening of human kinome, using three siRNAs for each of the ~700 known kinases represented in the human genome. Activity of alkaline phosphatase...