Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp132 | Cell biology: osteoblasts and bone formation | ECTS2014

Roles of phospholipase D during physiological and vascular calcification

Abdallah Dina , Hamade Eva , Badran Bassam , Buchet Rene , Mebarek Saida

There is a similarity of the mechanisms of physiological and pathological mineralization. Pathological calcification of soft tissues as the case of vascular calcification is characterized by the deposition of hydroxyapaptite induced by matrix vesicles at least in the initial stage as in the case of physiological calcification in skeletal tissues. Lipid metabolism is involved in the differentiation of smooth muscle cells and bone cells suggesting that phospholipases can modulat...