Searchable abstracts of presentations at key conferences on calcified tissues

ba0005oc5.4 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

Fine mapping of the chromosome 1p13 locus for susceptibility to Paget's disease of bone

Abdullah Fawaaz , Jin Huilin , Wani Sachin , Albagha Omar , Ralston Stuart

Introduction: Paget’s disease of bone (PDB) is a common disorder characterised by increased and disorganised bone remodelling. Previous genome wide association studies identified a locus for susceptibility to PDB on chromosome 1p13, tagged by rs484959 which lies 87 kb upstream of the CSF1 gene. This is a strong candidate for PDB since it encodes macrophage colony-stimulating factor (M-CSF) a critical cytokine for osteoclast formation and survival.Pu...