Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p151 | Cell biology: osteoblasts and bone formation | ECTS2016

Early deletion of menin in the osteoblast lineage results in decreased bone mass in adult mice

Abi Rafeh Jad , Canaff Lucie , Hendy Geoffrey

Menin, the product of the Men1 tumor suppressor gene, facilitates the cell proliferation control and differentiation induced by the TGF-beta superfamily of ligands critical for bone development and maintenance. Our in vivo studies have shown the importance of menin for proper functioning of the mature osteoblast and maintenance of bone mass in adult mice. In the present study, we examined the in vivo role of menin at earlier stages of the osteoblast lineage through conditional...