Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp168 | Cell biology: osteoclasts and bone resorption | ECTS2014

Effect of C-reactive protein on TRAP-positive multinucleated cell formation in RANKL-induced RAW264.7 cell culture

Choi Kyoung Hee , Hwang You Cheol , Jeong In-Kyung , Ahn Kyu Jeung , Chung Ho-Yeon

Inflammatory processes play a role in osteoclastogenesis. C-reactive protein (CRP), an acute phase reactant that reflects different degree of inflammation. More recently, accumulating evidence suggest that CRP is not only an inflammatory marker but also direct cause of diseases. Therefore, we examined the direct effects of CRP on osteoclast formation using RAW 264.7 cells. CRP significantly inhibited RANKL-induced TRAP-positive multinucleated cell formation in RAW 264.7 cell c...