Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp13 | Arthritis and other joint diseases: translational and clinical | ECTS2014

RANK expression is reduced in circulating monocytes from ankylosing spondylitis patients

Perpetuo Ines Pedro , Caetano-Lopes Joana , Vieira-Sousa Elsa , Campanilho-Marques Raquel , Ponte Cristina , Canhao Helena , Ainola Mari , Fonseca Joao Eurico

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RA’s main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients’ monocytes receive reduced osteoclastogenic stimuli and...