Searchable abstracts of presentations at key conferences on calcified tissues

ba0007oc27 | (1) | ICCBH2019

Palovarotene inhibits the development of new heterotopic ossification in fibrodysplasia ossificans progressiva (FOP)

Kaplan Frederick , Hsiao Edward C , Baujat Genevieve , Keen Richard , De Cunto Carmen , Di Rocco Maja , Brown Matthew A , Al Mukaddam Mona M , Grogan Donna R , Pignolo Robert J

Objective: FOP is a rare, severely disabling disease characterized by episodic flare-ups and accumulation of heterotopic ossification (HO) leading to restricted movement, physical disability, and early death. Data from two Phase 2 interventional studies and one natural history study (NHS) were used to evaluate whether palovarotene could reduce HO following an FOP flare-up.Methods: HO volume at the flare-up site was determined by CT at baseline and 12 wee...