ba0005p241 | Genetics and Epigenetics | ECTS2016
, The Clinical Vertebral Fracture Consortium Nerea
, Uitterlinden Andre
, Rivadeneira Fernando
, Ralston Stuart H
Vertebral fractures are the most common complication of osteoporosis, but little is known about the genetic determinants of susceptibility. Here we present the results of a genome wide association study in 1553 postmenopausal women with clinical vertebral fractures and 4340 controls, with replication in 667 cases and 2105 controls. A locus tagged by a less frequent variant (rs10190845, A-allele MAF=0.05) was identified on chromosome 2q13 as a strong predictor of clinical verte...