Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p124 | Cancer and bone: basic, translational and clinical | ECTS2016

Gene expression of P2 receptors in mitotically quiescent, prostate cancer bone metastasis initiating cells

Amin Zarkesh Sayyed , Docherty Freyja , Eaton Colby , Wang Ning

Rationale and hypothesis: In ~70% of advanced prostate cancer (PCa) patients, incurable bone metastases are a significant cause of morbidity and mortality. It has been shown that in models of PCa, bone metastases are initiated by a minor subset (<1% of total cell population) that are mitotically quiescent and which have undergone epithelial to mesenchymal transition (EMT). Recent studies have shown that various P2 receptors regulate invasiveness/EMT in different types of c...