Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp173 | Cell biology: osteoblasts and bone formation | ECTS2013

Exogenous polyphosphate is not readily utilized for mineralization in vitro

Ariganello Marianne , Omelon Sidney , Wazen Rima , Variola Fabio , Nanci Antonio

Polyphosphates (polyPs) are inorganic phosphate chains found in many cell types with higher concentrations in bone cells. As a source of inorganic phosphate (Pi) and an effective calcium reservoir due to chelation, PolyPs enable total Ca2+ and PO42− concentrations above those required for apatite saturation. Alkaline phosphatase (ALP) cleaves Pi from polyP, thus polyPs may be involved in apatite mineralization.Aim: ...