Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp183 | Cell biology: osteoblasts and bone formation | ECTS2013

Development of mice models to study implant osseointegration and failure in alveolar bone

Mouraret Sylvain , Bardet Claire , Hunter Dan J , Popelut Antoine , Brunski John B , Chaussain Catherine , Bouchard Philippe , Helms Jill A

Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones rather than in oral bones. This discrepancy between clinical practice and experimental research hampers our understanding on how alveolar bone forms or resorbs around implants and how osseointegration of oral implants can be improved. To overcome this disconnect, we have developed a mouse model which mimics oral implant placem...

ba0001pp469 | Other diseases of bone and mineral metabolism | ECTS2013

MEPE-derived ASARM peptide impairs mineralization in tooth models of X-linked hypophosphatemia

Salmon Benjamin , Bardet Claire , Khaddam Mayssam , Baroukh Brigitte , Lesieur Julie , Denmat Dominique Le , Nicoletti Antonino , Poliard Anne , Rowe Peter S , Linglart Agnes , McKee Marc D , Chaussain Catherine

Mutations in the PHEX gene cause X-linked familial hypophosphatemic rickets (XLH) with severe bone (osteomalacia) and tooth abnormalities being the distinguishing features of this disease. The PHEX mutations lead to an increase in ASARM peptides (acidic serine- and aspartate-rich motif) and osteopontin fragments which inhibit bone extracellular matrix mineralization. MEPE-derived ASARM has been shown to accumulate in tooth dentin of patients with XLH where it may impair dentin...