Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp317 | Osteoporosis: evaluation and imaging | ECTS2013

A 3D QCT technique of the thoracic and lumbar spine: integral volume and intervertebral disc space increase and bmd decreases from T6 to L4

Museyko Oleg , Heinemann Axel , Krause Mattias , Barkmann Reinhard , Amling Michael , Gluer Claus , Puschel Klaus , Engelke Klaus

Introduction: QCT of the spine is typically restricted to the BMD analysis of the lumbar vertebrae. However, fractures frequently occur in the thoracolumbar region. Also the load distribution in the spine may depend on the intervertebral disc space (IDS), a good approximation of the intervertebral disc, which itself cannot be reliably assessed by X-ray based methods.Materials and methods: A QCT 3D acquisition and automated analysis technique (with option...

ba0003pp236 | Osteoporosis: evaluation and imaging | ECTS2014

Improved assessment of vertebral cortex thickness by means of analytical deconvolution of radial bone mineral density distributions

Damm Timo , Pena Jaime , Bastgen Jan , Krause Matthias , Campbell Graeme , Barkmann Reinhard , Gluer Claus-Christian

New treatment agents against osteoporosis may not only lead to an improved trabecular structure, but can probably also strengthen the cortex. To assess this treatment effects by means of QCT, one has to deal with significant partial volume effects observing this very thin, but compact structure. A new method for cortical thickness estimation has been developed using an analytical deconvolution approach. After estimating the point-spread-function (PSF) of a scanner/kernel combi...

ba0005oc1.6 | Clinical trials and osteoporosis treatment | ECTS2016

Standard QCT shows substantial underestimation of treatment effects on bone mineral density: impact of spatial resolution

Reinhold Stefan , Damm Timo , Pena Jaime , Barkmann Reinhard , Gluer Claus-C

Quantitative Computed Tomography (QCT) can be performed with different protocols. We investigated whether selection of spatial resolution, reconstruction method, and scanner type have an impact on measured treatment effects for different bone compartments.Methods: In a multi-center study, a group of 50 men, age 55.1 (range 25–78) undergoing 18 months of either osteoanabolic (n=25) or antiresorptive treatment (n=25) were scanned wit...

ba0005p489 | Preclinical and ex vivo imaging | ECTS2016

Quantitative assessment of radial bone structural distribution in the proximity of degradable implants by micro-computed tomography

Damm Timo , Barkmann Reinhard , Galli Silvia , Willumeit-Romer Regine , Gluer Claus-Christian

Degradable bone implants may provide improved long-term healing, tissue remodeling and quality of life. In order to optimize alloy composition and degradation properties, in-vivo monitoring of the degradation process and its impact on bone formation is essential because degradation progresses differently in-vivo versus in-vitro. We aim to understand how degradation of magnesium alloy implants influences bone remodeling and bone structure using Micro-...

ba0003pp214 | Osteoporosis: evaluation and imaging | ECTS2014

Bone marrow densitometry by clinical high resolution computed tomography of human vertebrae

Pena Jaime , Campbell Graeme , Damm Timo , Barkmann Reinhard , Waldhausen Sonja , Thomsen Felix , Krause Matthias , Puschel Klaus , Gluer Claus C

Bone mineral density (BMD) as measured by quantitative computed tomography (QCT) is biased by the variable marrow composition since marrow fat reduces the apparent BMD. We developed a marrow densitometry (MD) method that identifies subvolumes in the vertebrae that consist of bone marrow only (bone voids) and determines their average mineral equivalent density values. The method was developed for use with in vivo high resolution QCT (HR-QCT). HR-QCT still has limited s...