Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p248 | Genetics and Epigenetics | ECTS2016

Identification and functional validation of microRNA expression in human bone tissue

Ostanek Barbara , Bedrac Simona Mencej , Kern Barbara , Vrtacnik Peter , Mlakar Vid , Bego Tamer , Komadina Radko , Trebše Rihard , Marc Janja

miRNAs are epigenetic regulators of gene expression, increasingly recognised as prominent regulators of bone metabolism. Following our in vitro studies of miRNAs profiles in osteoblasts we extended the research to human bone samples. Our aim was to find and functionally validate miRNAs differentially expressed in osteoporotic and osteoarthrotic bone with potential for targeting genes relevant in bone metabolism.Trabecular bone tissue samples wer...