Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp117 | Cell biology: osteoblasts and bone formation | ECTS2014

EGF inhibits Wnt/β-catenin-induced osteoblast differentiation in a Smurf1-dependent manner

Kwon Arang , Boonanantanasarn Kanitsak , Lee Hye-Lim , Woo Kyung Mi , Ryoo Hyun-Mo , Kim Gwan-Shik , Baek Jeong-Hwa

BMPs and canonical Wnts are the representative developmental signals that enhance osteoblast differentiation and bone formation. Previously, we demonstrated that EGF inhibits BMP2-induced osteoblast differentiation through the induction of Smurf1 expression. However, the regulatory role of EGF in Wnt/β-catenin-induced osteoblast differentiation has not been elucidated. In this study, we investigated the effect of EGF on Wnt/β-catenin signaling-induced osteoblast diff...