ba0003pp133 | Cell biology: osteoblasts and bone formation | ECTS2014
, Bozycki Lukasz
, Buchet Rene
, Pikula Slawomir
Bone cells control initial steps of mineralization by forming matrix vesicles (MVs) in which calcium and phosphate ions are accumulated. Under physiological conditions, MVs are released to the extracellular matrix (ECM) and Ca2+ and Pi form hydroxyapatite (HA). Growing minerals break the MVs membrane and are deposited in ECM. Under pathological conditions the mineralization process becomes deregulated, which leads to the formation of calcium phosphate deposits. It is suggested...