Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp156 | Cell biology: osteoclasts and bone resorption | ECTS2014

Interleukin-34 and macrophage-colony stimulating factor interact to form a heteromeric and functional cytokine

Segaliny Aude , Brion Regis , Brulin Benedicte , Teletchea Stephane , Jardin Julien , Maillasson Mike , Charrier Celine , Heymann Dominique

Interleukin-34 (IL-34) is a newly discovered cytokine which regulates, like macrophage-colony stimulating factor (M-CSF), the differentiation/activation of the myeloid lineage. IL-34 and M-CSF are homodimers known to bind to the M-CSF receptor (M-CSFR) in a competitive manner. In this system, IL-34 can substitute for the M-CSF to induce osteoclastic differentiation. The aim of the present work was to study the functional relationships of these cytokines on cells expressing the...