Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc3.4 | Osteoporosis pathophysiology and genetics | ECTS2013

Cortical exceeds trabecular bone loss before menopause but net bone loss is modest because periosteal apposition occurs

Bjornerem Ashild , Wang Xiaofang , Ghasem-Zadeh Ali , Bui Minh , Hopper John , Zebaze Roger , Seeman Ego

Introduction: Bone mineral density decreases before menopause and is held to be due to trabecular, not cortical, bone loss. Yet neither a negative bone balance, nor accelerated remodelling occurs before 45 years of age. We hypothesized that bone loss will first appear after 45 years and will be cortical (as 80% of bone is cortical).Methods/design: Images of distal tibia acquired using high-resolution peripheral quantitative computed tomography (Scanco Me...