Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p167 | Cell biology: osteoblasts and bone formation | ECTS2016

Implication of autophagy in a preclinical mouse model of bone ageing and of osteoporosis

Camuzard Olivier , Breuil Veronique , Santucci-Darmanin Sabine , Battaglia Severine , Heymann Dominique , Carle Georges , Pierrefite-Carle Valerie

Although estrogen deficiency has been considered for a long time as the main factor leading to osteoporosis (OP), several lines of evidence highlight the role of oxidative stress increase with age as a key factor in this pathology. Autophagy acts as a central mechanism allowing damaged macromolecules and organelles to be degraded and recycled, such as mitochondria, the main source of reactive oxygen species (ROS). Recent publications have shown that autophagy is a new actor in...